Phenotype Standardization of Angioedema in the Head and Neck Region Caused by Agents Acting on the Angiotensin System

Angioedema is a potentially life-threatening adverse reaction to angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. To study the genetic etiology of this rare adverse event, international consortia and multicenter recruitment of patients are needed. To reduce patient heterog...

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Autores principales: Wadelius, M, Marshall, S E, Islander, G, Nordang, L, Karawajczyk, M, Yue, Q-Y, Terreehorst, I, Baranova, E V, Hugosson, S, Sköldefors, K, Pirmohamed, M, Maitland-van der Zee, A-H, Alfirevic, A, Hallberg, P, Palmer, C N A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172548/
https://www.ncbi.nlm.nih.gov/pubmed/24960520
http://dx.doi.org/10.1038/clpt.2014.138
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author Wadelius, M
Marshall, S E
Islander, G
Nordang, L
Karawajczyk, M
Yue, Q-Y
Terreehorst, I
Baranova, E V
Hugosson, S
Sköldefors, K
Pirmohamed, M
Maitland-van der Zee, A-H
Alfirevic, A
Hallberg, P
Palmer, C N A
author_facet Wadelius, M
Marshall, S E
Islander, G
Nordang, L
Karawajczyk, M
Yue, Q-Y
Terreehorst, I
Baranova, E V
Hugosson, S
Sköldefors, K
Pirmohamed, M
Maitland-van der Zee, A-H
Alfirevic, A
Hallberg, P
Palmer, C N A
author_sort Wadelius, M
collection PubMed
description Angioedema is a potentially life-threatening adverse reaction to angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. To study the genetic etiology of this rare adverse event, international consortia and multicenter recruitment of patients are needed. To reduce patient heterogeneity, we have standardized the phenotype. In brief, it comprises swelling in the head and neck region that first occurs during treatment. It should not coincide with urticaria or have another likely cause such as hereditary angioedema.
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spelling pubmed-41725482014-10-01 Phenotype Standardization of Angioedema in the Head and Neck Region Caused by Agents Acting on the Angiotensin System Wadelius, M Marshall, S E Islander, G Nordang, L Karawajczyk, M Yue, Q-Y Terreehorst, I Baranova, E V Hugosson, S Sköldefors, K Pirmohamed, M Maitland-van der Zee, A-H Alfirevic, A Hallberg, P Palmer, C N A Clin Pharmacol Ther Review Angioedema is a potentially life-threatening adverse reaction to angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. To study the genetic etiology of this rare adverse event, international consortia and multicenter recruitment of patients are needed. To reduce patient heterogeneity, we have standardized the phenotype. In brief, it comprises swelling in the head and neck region that first occurs during treatment. It should not coincide with urticaria or have another likely cause such as hereditary angioedema. Nature Publishing Group 2014-10 2014-08-13 /pmc/articles/PMC4172548/ /pubmed/24960520 http://dx.doi.org/10.1038/clpt.2014.138 Text en Copyright © 2014 American Society for Clinical Pharmacology and Therapeutics http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Review
Wadelius, M
Marshall, S E
Islander, G
Nordang, L
Karawajczyk, M
Yue, Q-Y
Terreehorst, I
Baranova, E V
Hugosson, S
Sköldefors, K
Pirmohamed, M
Maitland-van der Zee, A-H
Alfirevic, A
Hallberg, P
Palmer, C N A
Phenotype Standardization of Angioedema in the Head and Neck Region Caused by Agents Acting on the Angiotensin System
title Phenotype Standardization of Angioedema in the Head and Neck Region Caused by Agents Acting on the Angiotensin System
title_full Phenotype Standardization of Angioedema in the Head and Neck Region Caused by Agents Acting on the Angiotensin System
title_fullStr Phenotype Standardization of Angioedema in the Head and Neck Region Caused by Agents Acting on the Angiotensin System
title_full_unstemmed Phenotype Standardization of Angioedema in the Head and Neck Region Caused by Agents Acting on the Angiotensin System
title_short Phenotype Standardization of Angioedema in the Head and Neck Region Caused by Agents Acting on the Angiotensin System
title_sort phenotype standardization of angioedema in the head and neck region caused by agents acting on the angiotensin system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172548/
https://www.ncbi.nlm.nih.gov/pubmed/24960520
http://dx.doi.org/10.1038/clpt.2014.138
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