Large-sized Fetal Striatal Grafts in Huntington’s Disease Do Stop Growing: Long-term Monitoring in the Florence Experience

Development of six large nodules of solid tissue after bilateral human fetal striatal transplantation in four Huntington’s disease patients has raised concern about the safety of this experimental therapy in our setting. We investigated by serial MRI-based volumetric analysis the growth behaviour of...

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Autores principales: Mascalchi, Mario, Diciotti, Stefano, Paganini, Marco, Bianchi, Andrea, Ginestroni, Andrea, Lombardini, Letizia, Porfirio, Berardino, Conti, Renato, Di Lorenzo, Nicola, Vannelli, Gabriella Barbara, Gallina, Pasquale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Clinical Assessment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172581/
https://www.ncbi.nlm.nih.gov/pubmed/25642368
http://dx.doi.org/10.1371/currents.hd.c0ad575f12106c38f9f5717a8a7d05ae
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author Mascalchi, Mario
Diciotti, Stefano
Paganini, Marco
Bianchi, Andrea
Ginestroni, Andrea
Lombardini, Letizia
Porfirio, Berardino
Conti, Renato
Di Lorenzo, Nicola
Vannelli, Gabriella Barbara
Gallina, Pasquale
author_facet Mascalchi, Mario
Diciotti, Stefano
Paganini, Marco
Bianchi, Andrea
Ginestroni, Andrea
Lombardini, Letizia
Porfirio, Berardino
Conti, Renato
Di Lorenzo, Nicola
Vannelli, Gabriella Barbara
Gallina, Pasquale
author_sort Mascalchi, Mario
collection PubMed
description Development of six large nodules of solid tissue after bilateral human fetal striatal transplantation in four Huntington’s disease patients has raised concern about the safety of this experimental therapy in our setting. We investigated by serial MRI-based volumetric analysis the growth behaviour of such grafts. After 33-73 months from transplantation the size of five grafts was stable and one graft showed a mild decrease in size. Signs neither of intracranial hypertension nor of adjuctive focal neurological deficit have ever been observed. This supports long-term safety of the grafting procedure at our Institution.
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spelling pubmed-41725812015-01-29 Large-sized Fetal Striatal Grafts in Huntington’s Disease Do Stop Growing: Long-term Monitoring in the Florence Experience Mascalchi, Mario Diciotti, Stefano Paganini, Marco Bianchi, Andrea Ginestroni, Andrea Lombardini, Letizia Porfirio, Berardino Conti, Renato Di Lorenzo, Nicola Vannelli, Gabriella Barbara Gallina, Pasquale PLoS Curr Clinical Assessment Development of six large nodules of solid tissue after bilateral human fetal striatal transplantation in four Huntington’s disease patients has raised concern about the safety of this experimental therapy in our setting. We investigated by serial MRI-based volumetric analysis the growth behaviour of such grafts. After 33-73 months from transplantation the size of five grafts was stable and one graft showed a mild decrease in size. Signs neither of intracranial hypertension nor of adjuctive focal neurological deficit have ever been observed. This supports long-term safety of the grafting procedure at our Institution. Public Library of Science 2014-08-04 /pmc/articles/PMC4172581/ /pubmed/25642368 http://dx.doi.org/10.1371/currents.hd.c0ad575f12106c38f9f5717a8a7d05ae Text en http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Clinical Assessment
Mascalchi, Mario
Diciotti, Stefano
Paganini, Marco
Bianchi, Andrea
Ginestroni, Andrea
Lombardini, Letizia
Porfirio, Berardino
Conti, Renato
Di Lorenzo, Nicola
Vannelli, Gabriella Barbara
Gallina, Pasquale
Large-sized Fetal Striatal Grafts in Huntington’s Disease Do Stop Growing: Long-term Monitoring in the Florence Experience
title Large-sized Fetal Striatal Grafts in Huntington’s Disease Do Stop Growing: Long-term Monitoring in the Florence Experience
title_full Large-sized Fetal Striatal Grafts in Huntington’s Disease Do Stop Growing: Long-term Monitoring in the Florence Experience
title_fullStr Large-sized Fetal Striatal Grafts in Huntington’s Disease Do Stop Growing: Long-term Monitoring in the Florence Experience
title_full_unstemmed Large-sized Fetal Striatal Grafts in Huntington’s Disease Do Stop Growing: Long-term Monitoring in the Florence Experience
title_short Large-sized Fetal Striatal Grafts in Huntington’s Disease Do Stop Growing: Long-term Monitoring in the Florence Experience
title_sort large-sized fetal striatal grafts in huntington’s disease do stop growing: long-term monitoring in the florence experience
topic Clinical Assessment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172581/
https://www.ncbi.nlm.nih.gov/pubmed/25642368
http://dx.doi.org/10.1371/currents.hd.c0ad575f12106c38f9f5717a8a7d05ae
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