PTEN Redundancy: Overexpressing lpten, a Homolog of Dictyostelium discoideum ptenA, the Ortholog of Human PTEN, Rescues All Behavioral Defects of the Mutant ptenA(−)

Mutations in the tumor suppressor gene PTEN are associated with a significant proportion of human cancers. Because the human genome also contains several homologs of PTEN, we considered the hypothesis that if a homolog, functionally redundant with PTEN, can be overexpressed, it may rescue the defect...

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Detalles Bibliográficos
Autores principales: Lusche, Daniel F., Wessels, Deborah, Richardson, Nicole A., Russell, Kanoe B., Hanson, Brett M., Soll, Benjamin A., Lin, Benjamin H., Soll, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172592/
https://www.ncbi.nlm.nih.gov/pubmed/25247494
http://dx.doi.org/10.1371/journal.pone.0108495

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