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Dietary intervention rescues maternal obesity induced behavior deficits and neuroinflammation in offspring
Obesity induces a low-grade inflammatory state and has been associated with behavioral and cognitive alterations. Importantly, maternal environmental insults can adversely impact subsequent offspring behavior and have been linked with neurodevelopmental disorders such as autism spectrum disorder (AS...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172780/ https://www.ncbi.nlm.nih.gov/pubmed/25212412 http://dx.doi.org/10.1186/s12974-014-0156-9 |
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author | Kang, Silvia S Kurti, Aishe Fair, Damien A Fryer, John D |
author_facet | Kang, Silvia S Kurti, Aishe Fair, Damien A Fryer, John D |
author_sort | Kang, Silvia S |
collection | PubMed |
description | Obesity induces a low-grade inflammatory state and has been associated with behavioral and cognitive alterations. Importantly, maternal environmental insults can adversely impact subsequent offspring behavior and have been linked with neurodevelopmental disorders such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (AHDH). It is unknown if maternal obesity significantly alters offspring sociability, a key ASD feature, and if altering maternal diet will provide an efficacious intervention paradigm for behavioral deficits. Here we investigated the impact of maternal high fat diet (HFD) and maternal dietary intervention during lactation on offspring behavior and brain inflammation in mice. We found that maternal HFD increased anxiety and decreased sociability in female offspring. Additionally, female offspring from HFD-fed dams also exhibited increased brain IL-1β and TNFα and microglial activation. Importantly, maternal dietary intervention during lactation was sufficient to alleviate social deficits and brain inflammation. Maternal obesity during gestation alone was sufficient to increase hyperactivity in male offspring, a phenotype that was not ameliorated by dietary intervention. These data suggest that maternal HFD acts as a prenatal/perinatal insult that significantly impacts offspring behavior and inflammation and that dietary intervention during lactation may be an easily translatable, efficacious intervention to offset some of these manifestations. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12974-014-0156-9) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4172780 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-41727802014-10-23 Dietary intervention rescues maternal obesity induced behavior deficits and neuroinflammation in offspring Kang, Silvia S Kurti, Aishe Fair, Damien A Fryer, John D J Neuroinflammation Research Obesity induces a low-grade inflammatory state and has been associated with behavioral and cognitive alterations. Importantly, maternal environmental insults can adversely impact subsequent offspring behavior and have been linked with neurodevelopmental disorders such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (AHDH). It is unknown if maternal obesity significantly alters offspring sociability, a key ASD feature, and if altering maternal diet will provide an efficacious intervention paradigm for behavioral deficits. Here we investigated the impact of maternal high fat diet (HFD) and maternal dietary intervention during lactation on offspring behavior and brain inflammation in mice. We found that maternal HFD increased anxiety and decreased sociability in female offspring. Additionally, female offspring from HFD-fed dams also exhibited increased brain IL-1β and TNFα and microglial activation. Importantly, maternal dietary intervention during lactation was sufficient to alleviate social deficits and brain inflammation. Maternal obesity during gestation alone was sufficient to increase hyperactivity in male offspring, a phenotype that was not ameliorated by dietary intervention. These data suggest that maternal HFD acts as a prenatal/perinatal insult that significantly impacts offspring behavior and inflammation and that dietary intervention during lactation may be an easily translatable, efficacious intervention to offset some of these manifestations. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12974-014-0156-9) contains supplementary material, which is available to authorized users. BioMed Central 2014-09-12 /pmc/articles/PMC4172780/ /pubmed/25212412 http://dx.doi.org/10.1186/s12974-014-0156-9 Text en © Kang et al.; licensee BioMed Central Ltd. 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Kang, Silvia S Kurti, Aishe Fair, Damien A Fryer, John D Dietary intervention rescues maternal obesity induced behavior deficits and neuroinflammation in offspring |
title | Dietary intervention rescues maternal obesity induced behavior deficits and neuroinflammation in offspring |
title_full | Dietary intervention rescues maternal obesity induced behavior deficits and neuroinflammation in offspring |
title_fullStr | Dietary intervention rescues maternal obesity induced behavior deficits and neuroinflammation in offspring |
title_full_unstemmed | Dietary intervention rescues maternal obesity induced behavior deficits and neuroinflammation in offspring |
title_short | Dietary intervention rescues maternal obesity induced behavior deficits and neuroinflammation in offspring |
title_sort | dietary intervention rescues maternal obesity induced behavior deficits and neuroinflammation in offspring |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172780/ https://www.ncbi.nlm.nih.gov/pubmed/25212412 http://dx.doi.org/10.1186/s12974-014-0156-9 |
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