Cargando…

Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer’s disease mouse model

BACKGROUND: Profound synapse loss is one of the major pathological hallmarks associated with Alzheimer’s disease, which might underlie memory impairment. Our previous work demonstrates that magnesium ion is a critical factor in controlling synapse density/plasticity. Here, we tested whether elevatio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Wei, Yu, Jia, Liu, Yong, Huang, Xiaojie, Abumaria, Nashat, Zhu, Ying, Huang, Xian, Xiong, Wenxiang, Ren, Chi, Liu, Xian-Guo, Chui, Dehua, Liu, Guosong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172865/ https://www.ncbi.nlm.nih.gov/pubmed/25213836 http://dx.doi.org/10.1186/s13041-014-0065-y

Ejemplares similares

Prevention of cognitive deficits in Alzheimer’s mouse model by elevating brain magnesium
por: Liu, Guosong
Publicado: (2012)

Neuroprotective Effects of TRPM7 Deletion in Parvalbumin GABAergic vs. Glutamatergic Neurons following Ischemia
por: Zhang, Pengju, et al.
Publicado: (2022)

Magnesium Protects Cognitive Functions and Synaptic Plasticity in Streptozotocin-Induced Sporadic Alzheimer’s Model
por: Xu, Zhi-Peng, et al.
Publicado: (2014)

Profiling and Co-expression Network Analysis of Learned Helplessness Regulated mRNAs and lncRNAs in the Mouse Hippocampus
por: Li, Chaoqun, et al.
Publicado: (2018)

Chronic psychosocial stress and citalopram modulate the expression of the glial proteins GFAP and NDRG2 in the hippocampus
por: Araya-Callís, Carolina, et al.
Publicado: (2012)

Therapeutic Potential of Neurotrophins for Repair After Brain Injury: A Helping Hand From Biomaterials
por: Houlton, Josh, et al.
Publicado: (2019)

Elevated phospholipase D isoform 1 in Alzheimer's disease patients' hippocampus: Relevance to synaptic dysfunction and memory deficits
por: Krishnan, Balaji, et al.
Publicado: (2018)

Mitochondrial Abnormalities and Synaptic Loss Underlie Memory Deficits Seen in Mouse Models of Obesity and Alzheimer’s Disease
por: Martins, Isaura V.A., et al.
Publicado: (2016)

Treatment Of Magnesium-L-Threonate Elevates The Magnesium Level In The Cerebrospinal Fluid And Attenuates Motor Deficits And Dopamine Neuron Loss In A Mouse Model Of Parkinson’s disease
por: Shen, Yanling, et al.
Publicado: (2019)

L-Norvaline Reverses Cognitive Decline and Synaptic Loss in a Murine Model of Alzheimer’s Disease
por: Polis, Baruh, et al.
Publicado: (2018)

The Causal Role of Magnesium Deficiency in the Neuroinflammation, Pain Hypersensitivity and Memory/Emotional Deficits in Ovariectomized and Aged Female Mice
por: Zhang, Jun, et al.
Publicado: (2021)

Levetiracetam Reverses Synaptic Deficits Produced by Overexpression of SV2A
por: Nowack, Amy, et al.
Publicado: (2011)

Compensating for thalamocortical synaptic loss in Alzheimer's disease
por: Abuhassan, Kamal, et al.
Publicado: (2014)

SPG302 Reverses Synaptic and Cognitive Deficits Without Altering Amyloid or Tau Pathology in a Transgenic Model of Alzheimer’s Disease
por: Trujillo-Estrada, Laura, et al.
Publicado: (2021)

Oridonin Attenuates Synaptic Loss and Cognitive Deficits in an Aβ(1–42)-Induced Mouse Model of Alzheimer’s Disease
por: Wang, Sulei, et al.
Publicado: (2016)

Characteristic Features of Deep Brain Lymphatic Vessels and Their Regulation by Chronic Stress
por: Chang, Junzhuang, et al.
Publicado: (2023)

Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice
por: Elmore, Monica R. P., et al.
Publicado: (2018)

Erythrocyte intracellular Mg(2+) concentration as an index of recognition and memory
por: Xiong, Wenxiang, et al.
Publicado: (2016)

S-Ketamine Rapidly Reverses Synaptic and Vascular Deficits of Hippocampus in Genetic Animal Model of Depression
por: Ardalan, Maryam, et al.
Publicado: (2016)

RhoA-ROCK Inhibition Reverses Synaptic Remodeling and Motor and Cognitive Deficits Caused by Traumatic Brain Injury
por: Mulherkar, Shalaka, et al.
Publicado: (2017)

Pinpointing Synaptic Loss Caused by Alzheimer’s Disease with fMRI
por: Brickman, Adam M., et al.
Publicado: (2009)

Preventing synaptic deficits in Alzheimer’s disease by inhibiting tumor necrosis factor alpha signaling
por: Cavanagh, Chelsea, et al.
Publicado: (2018)

A metabolite attenuates neuroinflammation, synaptic loss and cognitive deficits induced by chronic infection of Toxoplasma gondii
por: He, Yan, et al.
Publicado: (2022)

Paternal spatial training enhances offspring’s cognitive performance and synaptic plasticity in wild-type but not improve memory deficit in Alzheimer’s mice
por: Zhang, Shujuan, et al.
Publicado: (2017)

Insulin-like growth factor 2 reverses memory and synaptic deficits in APP transgenic mice
por: Pascual-Lucas, Maria, et al.
Publicado: (2014)

Hydrogen Sulfide Reverses Aging-Associated Amygdalar Synaptic Plasticity and Fear Memory Deficits in Rats
por: Zhan, Jin-Qiong, et al.
Publicado: (2018)

p85S6K sustains synaptic GluA1 to ameliorate cognitive deficits in Alzheimer’s disease
por: Li, Jia-Bing, et al.
Publicado: (2023)

In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET
por: Mecca, Adam P., et al.
Publicado: (2020)

Magnesium Deficiency Causes a Reversible, Metabolic, Diastolic Cardiomyopathy
por: Liu, Man, et al.
Publicado: (2021)

M2 cortex-dorsolateral striatum stimulation reverses motor symptoms and synaptic deficits in Huntington’s disease
por: Fernández-García, Sara, et al.
Publicado: (2020)

Inhibition of endoplasmic reticulum stress reverses synaptic plasticity deficits in striatum of DYT1 dystonia mice
por: Cai, Huaying, et al.
Publicado: (2021)

Isoflurane mediated neuropathological and cognitive impairments in the triple transgenic Alzheimer’s mouse model are associated with hippocampal synaptic deficits in an age-dependent manner
por: Joseph, Donald J., et al.
Publicado: (2019)

Established Beta Amyloid Pathology Is Unaffected by TREM2 Elevation in Reactive Microglia in an Alzheimer’s Disease Mouse Model
por: Yuan, Qiuju, et al.
Publicado: (2021)

An Intracellular Threonine of Amyloid-β Precursor Protein Mediates Synaptic Plasticity Deficits and Memory Loss
por: Lombino, Franco, et al.
Publicado: (2013)

The Reversal of Memory Deficits in an Alzheimer’s Disease Model Using Physical and Cognitive Exercise
por: Dare, Leticia R., et al.
Publicado: (2020)

Untangling the association of amyloid-β and tau with synaptic and axonal loss in Alzheimer’s disease
por: Pereira, Joana B, et al.
Publicado: (2020)

Terminal complement pathway activation drives synaptic loss in Alzheimer’s disease models
por: Carpanini, Sarah M., et al.
Publicado: (2022)

Commentary: The Flavonoid Baicalein Rescues Synaptic Plasticity and Memory Deficits in a Mouse Model of Alzheimer’s Disease
por: Chirumbolo, Salvatore, et al.
Publicado: (2016)

Targeting histone K4 trimethylation for treatment of cognitive and synaptic deficits in mouse models of Alzheimer’s disease
por: Cao, Qing, et al.
Publicado: (2020)

Improved Corrosion Resistance of Magnesium Alloy in Simulated Concrete Pore Solution by Hydrothermal Treatment
por: Wang, Ye, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_s3v37v1b2ggbu60j68fl705gcr