Inhibition of phosphodiesterase 5 restores endothelial function in renovascular hypertension

BACKGROUND: The clipping of an artery supplying one of the two kidneys (2K1C) activates the renin-angiotensin (Ang) system (RAS), resulting in hypertension and endothelial dysfunction. Recently, we demonstrated the intrarenal beneficial effects of sildenafil on the high levels of Ang II and reactive...

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Detalles Bibliográficos
Autores principales: Dias, Ananda T, Cintra, Amanda S, Frossard, Jéssica C, Palomino, Zaira, Casarini, Dulce E, Gomes, Isabele BS, Balarini, Camille M, Gava, Agata L, Campagnaro, Bianca P, Pereira, Thiago MC, Meyrelles, Silvana S, Vasquez, Elisardo C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172908/
https://www.ncbi.nlm.nih.gov/pubmed/25223948
http://dx.doi.org/10.1186/s12967-014-0250-x

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