Glatiramer Acetate and Nanny Proteins Restrict Access of the Multiple Sclerosis Autoantigen Myelin Basic Protein to the 26S Proteasome

We recently showed that myelin basic protein (MBP) is hydrolyzed by 26S proteasome without ubiquitination. The previously suggested concept of charge-mediated interaction between MBP and the proteasome led us to attempt to compensate or mimic its positive charge to inhibit proteasomal degradation. W...

Descripción completa

Detalles Bibliográficos
Autores principales: Kuzina, Ekaterina, Kudriaeva, Anna, Smirnov, Ivan, Dubina, Michael V., Gabibov, Alexander, Belogurov, Alexey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172982/
https://www.ncbi.nlm.nih.gov/pubmed/25276831
http://dx.doi.org/10.1155/2014/926394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172982/
https://www.ncbi.nlm.nih.gov/pubmed/25276831
http://dx.doi.org/10.1155/2014/926394

Ejemplares similares