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Improving the accuracy of the structure prediction of the third hypervariable loop of the heavy chains of antibodies
Motivation: Antibodies are able to recognize a wide range of antigens through their complementary determining regions formed by six hypervariable loops. Predicting the 3D structure of these loops is essential for the analysis and reengineering of novel antibodies with enhanced affinity and specifici...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173008/ https://www.ncbi.nlm.nih.gov/pubmed/24930144 http://dx.doi.org/10.1093/bioinformatics/btu194 |