RAREMETAL: fast and powerful meta-analysis for rare variants

Summary: RAREMETAL is a computationally efficient tool for meta-analysis of rare variants genotyped using sequencing or arrays. RAREMETAL facilitates analyses of individual studies, accommodates a variety of input file formats, handles related and unrelated individuals, executes both single variant...

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Detalles Bibliográficos
Autores principales: Feng, Shuang, Liu, Dajiang, Zhan, Xiaowei, Wing, Mary Kate, Abecasis, Gonçalo R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Applications Notes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173011/
https://www.ncbi.nlm.nih.gov/pubmed/24894501
http://dx.doi.org/10.1093/bioinformatics/btu367
Descripción
Sumario:Summary: RAREMETAL is a computationally efficient tool for meta-analysis of rare variants genotyped using sequencing or arrays. RAREMETAL facilitates analyses of individual studies, accommodates a variety of input file formats, handles related and unrelated individuals, executes both single variant and burden tests and performs conditional association analyses. Availability and implementation: http://genome.sph.umich.edu/wiki/RAREMETAL for executables, source code, documentation and tutorial. Contact: sfengsph@umich.edu or goncalo@umich.edu

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