Association between cyclin D1 G870A polymorphism and cervical cancer risk: a cumulative meta-analysis involving 2,864 patients and 3,898 controls

BACKGROUND: Association between Cyclin D1 (CCND1) polymorphism and cervical cancer risk are conflicting with published articles. We performed a meta-analysis to investigate the association between CCND1 G870A polymorphism and cervical cancer risk. METHODS: PubMed, Embase and CNKI data were researched to conduct a meta-analysis on the associations between CCND1 G870A polymorphism and cervical cancer risk. Ten published case–control studies including 2,864 patients with cervical cancer and 3,898 controls were collected in this meta-analysis. Odds ratio (OR) with 95% confidence interval (CI) were applied to assess the relationship; meta-regression, sensitivity analysis and cumulative analysis were also conducted to guarantee the strength of results. RESULTS: Overall, no significant association between CCND1 G870A polymorphism and cervical cancer risk were found in allele contrast (A vs. G: OR = 1.02, 95% CI = 0.88-1.19, P = 0.76 I(2) = 74.5%), codominant model (GA vs. GG: OR = 0.98, 95% CI = 0.77-1.26, P = 0.90 I(2) = 69.1%; AA vs GG: OR = 1.03, 95% CI = 0.75-1.41, P = 0.85 I(2) = 75.9%), dominant model (GA + AA vs. GG: OR = 1.00, 95% CI = 0.78-1.28, P = 0.99 I(2) = 72.3%) and recessive model (AA vs GG + GA: OR = 1.06, 95% CI = 0.85-1.23, P = 0.62, I(2) = 70.1%). Similarly, in the stratified analysis by ethnicity, study design and genotyping type, no significant association detected in all genetic models either. CONCLUSIONS: Our meta-analysis indicated that CCND1 G870A might be not the crucial risk factor for the development of cervical cancer. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_168