Cerebrospinal Fluid Aquaporin-4 Antibody Levels in Neuromyelitis Optica Attacks

To elucidate immunopathogenetic roles of aquaporin-4 antibodies in the cerebrospinal fluid (CSF) of neuromyelitis optica spectrum disorders (NMOSD), we analyzed aquaporin-4 antibody titers, cellular and inflammatory markers in the CSF collected from 11 aquaporin-4 antibody seropositive patients. The...

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Autores principales: Sato, Douglas Kazutoshi, Callegaro, Dagoberto, de Haidar Jorge, Frederico M, Nakashima, Ichiro, Nishiyama, Shuhei, Takahashi, Toshiyuki, Simm, Renata Faria, Apostolos-Pereira, Samira Luisa, Misu, Tatsuro, Steinman, Lawrence, Aoki, Masashi, Fujihara, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173125/
https://www.ncbi.nlm.nih.gov/pubmed/24977390
http://dx.doi.org/10.1002/ana.24208
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author Sato, Douglas Kazutoshi
Callegaro, Dagoberto
de Haidar Jorge, Frederico M
Nakashima, Ichiro
Nishiyama, Shuhei
Takahashi, Toshiyuki
Simm, Renata Faria
Apostolos-Pereira, Samira Luisa
Misu, Tatsuro
Steinman, Lawrence
Aoki, Masashi
Fujihara, Kazuo
author_facet Sato, Douglas Kazutoshi
Callegaro, Dagoberto
de Haidar Jorge, Frederico M
Nakashima, Ichiro
Nishiyama, Shuhei
Takahashi, Toshiyuki
Simm, Renata Faria
Apostolos-Pereira, Samira Luisa
Misu, Tatsuro
Steinman, Lawrence
Aoki, Masashi
Fujihara, Kazuo
author_sort Sato, Douglas Kazutoshi
collection PubMed
description To elucidate immunopathogenetic roles of aquaporin-4 antibodies in the cerebrospinal fluid (CSF) of neuromyelitis optica spectrum disorders (NMOSD), we analyzed aquaporin-4 antibody titers, cellular and inflammatory markers in the CSF collected from 11 aquaporin-4 antibody seropositive patients. The CSF aquaporin-4 antibody levels during attacks (but not in sera) closely correlated with pleocytosis, inflammatory cytokines including interleukin-6 that can regulate antibody-producing plasmablasts, and glial fibrillary acidic protein levels in the CSF. The amount of aquaporin-4 antibodies present in the central nervous system may have therapeutic implications, as it is associated with astrocyte injury and inflammatory responses during NMOSD attacks. Ann Neurol 2014;76:305–309
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spelling pubmed-41731252014-10-08 Cerebrospinal Fluid Aquaporin-4 Antibody Levels in Neuromyelitis Optica Attacks Sato, Douglas Kazutoshi Callegaro, Dagoberto de Haidar Jorge, Frederico M Nakashima, Ichiro Nishiyama, Shuhei Takahashi, Toshiyuki Simm, Renata Faria Apostolos-Pereira, Samira Luisa Misu, Tatsuro Steinman, Lawrence Aoki, Masashi Fujihara, Kazuo Ann Neurol Brief Communications To elucidate immunopathogenetic roles of aquaporin-4 antibodies in the cerebrospinal fluid (CSF) of neuromyelitis optica spectrum disorders (NMOSD), we analyzed aquaporin-4 antibody titers, cellular and inflammatory markers in the CSF collected from 11 aquaporin-4 antibody seropositive patients. The CSF aquaporin-4 antibody levels during attacks (but not in sera) closely correlated with pleocytosis, inflammatory cytokines including interleukin-6 that can regulate antibody-producing plasmablasts, and glial fibrillary acidic protein levels in the CSF. The amount of aquaporin-4 antibodies present in the central nervous system may have therapeutic implications, as it is associated with astrocyte injury and inflammatory responses during NMOSD attacks. Ann Neurol 2014;76:305–309 Blackwell Publishing Ltd 2014-08 2014-07-09 /pmc/articles/PMC4173125/ /pubmed/24977390 http://dx.doi.org/10.1002/ana.24208 Text en © 2014 The Authors Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Brief Communications
Sato, Douglas Kazutoshi
Callegaro, Dagoberto
de Haidar Jorge, Frederico M
Nakashima, Ichiro
Nishiyama, Shuhei
Takahashi, Toshiyuki
Simm, Renata Faria
Apostolos-Pereira, Samira Luisa
Misu, Tatsuro
Steinman, Lawrence
Aoki, Masashi
Fujihara, Kazuo
Cerebrospinal Fluid Aquaporin-4 Antibody Levels in Neuromyelitis Optica Attacks
title Cerebrospinal Fluid Aquaporin-4 Antibody Levels in Neuromyelitis Optica Attacks
title_full Cerebrospinal Fluid Aquaporin-4 Antibody Levels in Neuromyelitis Optica Attacks
title_fullStr Cerebrospinal Fluid Aquaporin-4 Antibody Levels in Neuromyelitis Optica Attacks
title_full_unstemmed Cerebrospinal Fluid Aquaporin-4 Antibody Levels in Neuromyelitis Optica Attacks
title_short Cerebrospinal Fluid Aquaporin-4 Antibody Levels in Neuromyelitis Optica Attacks
title_sort cerebrospinal fluid aquaporin-4 antibody levels in neuromyelitis optica attacks
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173125/
https://www.ncbi.nlm.nih.gov/pubmed/24977390
http://dx.doi.org/10.1002/ana.24208
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