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Setdb1 is required for germline development and silencing of H3K9me3-marked endogenous retroviruses in primordial germ cells
Transcription of endogenous retroviruses (ERVs) is inhibited by de novo DNA methylation during gametogenesis, a process initiated after birth in oocytes and at approximately embryonic day 15.5 (E15.5) in prospermatogonia. Earlier in germline development, the genome, including most retrotransposons,...
Autores principales: | Liu, Sheng, Brind’Amour, Julie, Karimi, Mohammad M., Shirane, Kenjiro, Bogutz, Aaron, Lefebvre, Louis, Sasaki, Hiroyuki, Shinkai, Yoichi, Lorincz, Matthew C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173156/ https://www.ncbi.nlm.nih.gov/pubmed/25228647 http://dx.doi.org/10.1101/gad.244848.114 |
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