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The prophylactic role of tranexamic acid to reduce blood loss during radical surgery: A prospective study

BACKGROUND: The radical surgical procedures are associated with perioperative blood loss. This study was aimed to evaluate the clinical efficacy and safety of tranexamic acid in reducing perioperative blood loss in patients undergoing radical surgery. MATERIALS AND METHODS: Sixty ASA class I and II...

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Autores principales: Gupta, Kumkum, Rastogi, Bhawna, Krishan, Atul, Gupta, Amit, Singh, V. P., Agarwal, Salony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173437/
https://www.ncbi.nlm.nih.gov/pubmed/25885506
http://dx.doi.org/10.4103/0259-1162.103378
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author Gupta, Kumkum
Rastogi, Bhawna
Krishan, Atul
Gupta, Amit
Singh, V. P.
Agarwal, Salony
author_facet Gupta, Kumkum
Rastogi, Bhawna
Krishan, Atul
Gupta, Amit
Singh, V. P.
Agarwal, Salony
author_sort Gupta, Kumkum
collection PubMed
description BACKGROUND: The radical surgical procedures are associated with perioperative blood loss. This study was aimed to evaluate the clinical efficacy and safety of tranexamic acid in reducing perioperative blood loss in patients undergoing radical surgery. MATERIALS AND METHODS: Sixty ASA class I and II adult consented female patients, scheduled for elective radical surgery and met the inclusion criterion, were blindly randomized into two groups to receive either intravenous 1 g tranexamic acid 20 min before skin incision or an equivalent volume of normal saline as placebo (P). All patient's total blood loss was measured and recorded perioperatively at the 12(th)h postoperatively. The preoperative and postoperative hemoglobin, hematocrit values, serum creatinine, activated thromboplastin time, prothombin time, thrombocyte count, fibrinogen, D-dimer, and symptoms of pulmonary embolism were comparatively evaluated. RESULTS: The tranexamic acid significantly reduced the quantity of total blood loss, 576 ± 53 mL in study group as compared to 823 ± 74 mL in the control group (P<0.01). Postoperatively hematocrit values were higher in the tranexamic acid group. The coagulation profile did not differ between the groups, but D-dimer concentrations were increased in the control group. No complications or adverse effects were reported in the either group. CONCLUSION: The prophylactic administration of tranexamic acid has effectively reduced theblood loss and transfusion needs during radical surgery without any adverse effects or complication of thrombosis.
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spelling pubmed-41734372014-10-22 The prophylactic role of tranexamic acid to reduce blood loss during radical surgery: A prospective study Gupta, Kumkum Rastogi, Bhawna Krishan, Atul Gupta, Amit Singh, V. P. Agarwal, Salony Anesth Essays Res Original Article BACKGROUND: The radical surgical procedures are associated with perioperative blood loss. This study was aimed to evaluate the clinical efficacy and safety of tranexamic acid in reducing perioperative blood loss in patients undergoing radical surgery. MATERIALS AND METHODS: Sixty ASA class I and II adult consented female patients, scheduled for elective radical surgery and met the inclusion criterion, were blindly randomized into two groups to receive either intravenous 1 g tranexamic acid 20 min before skin incision or an equivalent volume of normal saline as placebo (P). All patient's total blood loss was measured and recorded perioperatively at the 12(th)h postoperatively. The preoperative and postoperative hemoglobin, hematocrit values, serum creatinine, activated thromboplastin time, prothombin time, thrombocyte count, fibrinogen, D-dimer, and symptoms of pulmonary embolism were comparatively evaluated. RESULTS: The tranexamic acid significantly reduced the quantity of total blood loss, 576 ± 53 mL in study group as compared to 823 ± 74 mL in the control group (P<0.01). Postoperatively hematocrit values were higher in the tranexamic acid group. The coagulation profile did not differ between the groups, but D-dimer concentrations were increased in the control group. No complications or adverse effects were reported in the either group. CONCLUSION: The prophylactic administration of tranexamic acid has effectively reduced theblood loss and transfusion needs during radical surgery without any adverse effects or complication of thrombosis. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC4173437/ /pubmed/25885506 http://dx.doi.org/10.4103/0259-1162.103378 Text en Copyright: © Anesthesia: Essays and Researches http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Gupta, Kumkum
Rastogi, Bhawna
Krishan, Atul
Gupta, Amit
Singh, V. P.
Agarwal, Salony
The prophylactic role of tranexamic acid to reduce blood loss during radical surgery: A prospective study
title The prophylactic role of tranexamic acid to reduce blood loss during radical surgery: A prospective study
title_full The prophylactic role of tranexamic acid to reduce blood loss during radical surgery: A prospective study
title_fullStr The prophylactic role of tranexamic acid to reduce blood loss during radical surgery: A prospective study
title_full_unstemmed The prophylactic role of tranexamic acid to reduce blood loss during radical surgery: A prospective study
title_short The prophylactic role of tranexamic acid to reduce blood loss during radical surgery: A prospective study
title_sort prophylactic role of tranexamic acid to reduce blood loss during radical surgery: a prospective study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173437/
https://www.ncbi.nlm.nih.gov/pubmed/25885506
http://dx.doi.org/10.4103/0259-1162.103378
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