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Comparison of intubating conditions following administration of low-dose rocuronium or succinylcholine in adults: A randomized double blind study

CONTEXT: Though rocuronium has a rapid onset of neuromuscular blockade like succinylcholine without the latter's adverse effects, its use is limited due to its prolonged action. AIM: Aim was to evaluate whether reducing the intubating dose of rocuronium shortens its duration of action, yet prov...

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Autores principales: Venkateswaran, Ramkumar, Chaudhuri, Souvik, Deepak, K. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173439/
https://www.ncbi.nlm.nih.gov/pubmed/25885505
http://dx.doi.org/10.4103/0259-1162.103377
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author Venkateswaran, Ramkumar
Chaudhuri, Souvik
Deepak, K. M.
author_facet Venkateswaran, Ramkumar
Chaudhuri, Souvik
Deepak, K. M.
author_sort Venkateswaran, Ramkumar
collection PubMed
description CONTEXT: Though rocuronium has a rapid onset of neuromuscular blockade like succinylcholine without the latter's adverse effects, its use is limited due to its prolonged action. AIM: Aim was to evaluate whether reducing the intubating dose of rocuronium shortens its duration of action, yet provides clinically acceptable intubating conditions. SETTINGS AND DESIGN: tt was a prospective, randomized, and double blind trial. MATERIALS AND METHODS: 100 American Society of Anaesthesiologists Physical Status (ASAPS) I or II patients aged between 18–65 years scheduled for elective surgery were randomly allotted one of the four rocuronium groups (rocuronium dose of 0.3 mg/kg intubated at 60 s or at 90 s, rocuronium 0.6 mg/kg intubated at 60 s or at 90 s) orsuccinylcholine group (succinylcholine 1.0 mg/kg intubated at 60 s) and intubating conditions were assessed with: Ease of laryngoscopy, vocal cord position, and reaction to insertion of tracheal tube and cuff inflation. STATISTICAL ANALYSIS: Statistical tests used were analysis of variance (ANOVA), Chi-Square test, Repeated measures of ANOVA and Mann–Whitney U test. RESULTS: Rocuronium in dosage of 0.3 mg/kg gaveclinically acceptable intubating conditions in 35% and 60% subjects at 60 s or 90 s, respectively, whereas in dosage of 0.6 mg/kg, intubating conditions were acceptable in 80% and 100% subjects intubated at 60 s and 90 s. CONCLUSION: Rocuronium in dose of 0.3 mg/kg does not give clinically acceptable intubating conditions at 60 or 90 s but has shorter duration of action. Rocuronium in dose of 0.6 mg/kg gives clinically acceptable intubating conditions at 60 or 90 s, comparable to succinylcholine 1 mg/kg.
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spelling pubmed-41734392014-10-22 Comparison of intubating conditions following administration of low-dose rocuronium or succinylcholine in adults: A randomized double blind study Venkateswaran, Ramkumar Chaudhuri, Souvik Deepak, K. M. Anesth Essays Res Original Article CONTEXT: Though rocuronium has a rapid onset of neuromuscular blockade like succinylcholine without the latter's adverse effects, its use is limited due to its prolonged action. AIM: Aim was to evaluate whether reducing the intubating dose of rocuronium shortens its duration of action, yet provides clinically acceptable intubating conditions. SETTINGS AND DESIGN: tt was a prospective, randomized, and double blind trial. MATERIALS AND METHODS: 100 American Society of Anaesthesiologists Physical Status (ASAPS) I or II patients aged between 18–65 years scheduled for elective surgery were randomly allotted one of the four rocuronium groups (rocuronium dose of 0.3 mg/kg intubated at 60 s or at 90 s, rocuronium 0.6 mg/kg intubated at 60 s or at 90 s) orsuccinylcholine group (succinylcholine 1.0 mg/kg intubated at 60 s) and intubating conditions were assessed with: Ease of laryngoscopy, vocal cord position, and reaction to insertion of tracheal tube and cuff inflation. STATISTICAL ANALYSIS: Statistical tests used were analysis of variance (ANOVA), Chi-Square test, Repeated measures of ANOVA and Mann–Whitney U test. RESULTS: Rocuronium in dosage of 0.3 mg/kg gaveclinically acceptable intubating conditions in 35% and 60% subjects at 60 s or 90 s, respectively, whereas in dosage of 0.6 mg/kg, intubating conditions were acceptable in 80% and 100% subjects intubated at 60 s and 90 s. CONCLUSION: Rocuronium in dose of 0.3 mg/kg does not give clinically acceptable intubating conditions at 60 or 90 s but has shorter duration of action. Rocuronium in dose of 0.6 mg/kg gives clinically acceptable intubating conditions at 60 or 90 s, comparable to succinylcholine 1 mg/kg. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC4173439/ /pubmed/25885505 http://dx.doi.org/10.4103/0259-1162.103377 Text en Copyright: © Anesthesia: Essays and Researches http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Venkateswaran, Ramkumar
Chaudhuri, Souvik
Deepak, K. M.
Comparison of intubating conditions following administration of low-dose rocuronium or succinylcholine in adults: A randomized double blind study
title Comparison of intubating conditions following administration of low-dose rocuronium or succinylcholine in adults: A randomized double blind study
title_full Comparison of intubating conditions following administration of low-dose rocuronium or succinylcholine in adults: A randomized double blind study
title_fullStr Comparison of intubating conditions following administration of low-dose rocuronium or succinylcholine in adults: A randomized double blind study
title_full_unstemmed Comparison of intubating conditions following administration of low-dose rocuronium or succinylcholine in adults: A randomized double blind study
title_short Comparison of intubating conditions following administration of low-dose rocuronium or succinylcholine in adults: A randomized double blind study
title_sort comparison of intubating conditions following administration of low-dose rocuronium or succinylcholine in adults: a randomized double blind study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173439/
https://www.ncbi.nlm.nih.gov/pubmed/25885505
http://dx.doi.org/10.4103/0259-1162.103377
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