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Comparison of intubating conditions following administration of low-dose rocuronium or succinylcholine in adults: A randomized double blind study
CONTEXT: Though rocuronium has a rapid onset of neuromuscular blockade like succinylcholine without the latter's adverse effects, its use is limited due to its prolonged action. AIM: Aim was to evaluate whether reducing the intubating dose of rocuronium shortens its duration of action, yet prov...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173439/ https://www.ncbi.nlm.nih.gov/pubmed/25885505 http://dx.doi.org/10.4103/0259-1162.103377 |
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author | Venkateswaran, Ramkumar Chaudhuri, Souvik Deepak, K. M. |
author_facet | Venkateswaran, Ramkumar Chaudhuri, Souvik Deepak, K. M. |
author_sort | Venkateswaran, Ramkumar |
collection | PubMed |
description | CONTEXT: Though rocuronium has a rapid onset of neuromuscular blockade like succinylcholine without the latter's adverse effects, its use is limited due to its prolonged action. AIM: Aim was to evaluate whether reducing the intubating dose of rocuronium shortens its duration of action, yet provides clinically acceptable intubating conditions. SETTINGS AND DESIGN: tt was a prospective, randomized, and double blind trial. MATERIALS AND METHODS: 100 American Society of Anaesthesiologists Physical Status (ASAPS) I or II patients aged between 18–65 years scheduled for elective surgery were randomly allotted one of the four rocuronium groups (rocuronium dose of 0.3 mg/kg intubated at 60 s or at 90 s, rocuronium 0.6 mg/kg intubated at 60 s or at 90 s) orsuccinylcholine group (succinylcholine 1.0 mg/kg intubated at 60 s) and intubating conditions were assessed with: Ease of laryngoscopy, vocal cord position, and reaction to insertion of tracheal tube and cuff inflation. STATISTICAL ANALYSIS: Statistical tests used were analysis of variance (ANOVA), Chi-Square test, Repeated measures of ANOVA and Mann–Whitney U test. RESULTS: Rocuronium in dosage of 0.3 mg/kg gaveclinically acceptable intubating conditions in 35% and 60% subjects at 60 s or 90 s, respectively, whereas in dosage of 0.6 mg/kg, intubating conditions were acceptable in 80% and 100% subjects intubated at 60 s and 90 s. CONCLUSION: Rocuronium in dose of 0.3 mg/kg does not give clinically acceptable intubating conditions at 60 or 90 s but has shorter duration of action. Rocuronium in dose of 0.6 mg/kg gives clinically acceptable intubating conditions at 60 or 90 s, comparable to succinylcholine 1 mg/kg. |
format | Online Article Text |
id | pubmed-4173439 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-41734392014-10-22 Comparison of intubating conditions following administration of low-dose rocuronium or succinylcholine in adults: A randomized double blind study Venkateswaran, Ramkumar Chaudhuri, Souvik Deepak, K. M. Anesth Essays Res Original Article CONTEXT: Though rocuronium has a rapid onset of neuromuscular blockade like succinylcholine without the latter's adverse effects, its use is limited due to its prolonged action. AIM: Aim was to evaluate whether reducing the intubating dose of rocuronium shortens its duration of action, yet provides clinically acceptable intubating conditions. SETTINGS AND DESIGN: tt was a prospective, randomized, and double blind trial. MATERIALS AND METHODS: 100 American Society of Anaesthesiologists Physical Status (ASAPS) I or II patients aged between 18–65 years scheduled for elective surgery were randomly allotted one of the four rocuronium groups (rocuronium dose of 0.3 mg/kg intubated at 60 s or at 90 s, rocuronium 0.6 mg/kg intubated at 60 s or at 90 s) orsuccinylcholine group (succinylcholine 1.0 mg/kg intubated at 60 s) and intubating conditions were assessed with: Ease of laryngoscopy, vocal cord position, and reaction to insertion of tracheal tube and cuff inflation. STATISTICAL ANALYSIS: Statistical tests used were analysis of variance (ANOVA), Chi-Square test, Repeated measures of ANOVA and Mann–Whitney U test. RESULTS: Rocuronium in dosage of 0.3 mg/kg gaveclinically acceptable intubating conditions in 35% and 60% subjects at 60 s or 90 s, respectively, whereas in dosage of 0.6 mg/kg, intubating conditions were acceptable in 80% and 100% subjects intubated at 60 s and 90 s. CONCLUSION: Rocuronium in dose of 0.3 mg/kg does not give clinically acceptable intubating conditions at 60 or 90 s but has shorter duration of action. Rocuronium in dose of 0.6 mg/kg gives clinically acceptable intubating conditions at 60 or 90 s, comparable to succinylcholine 1 mg/kg. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC4173439/ /pubmed/25885505 http://dx.doi.org/10.4103/0259-1162.103377 Text en Copyright: © Anesthesia: Essays and Researches http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Venkateswaran, Ramkumar Chaudhuri, Souvik Deepak, K. M. Comparison of intubating conditions following administration of low-dose rocuronium or succinylcholine in adults: A randomized double blind study |
title | Comparison of intubating conditions following administration of low-dose rocuronium or succinylcholine in adults: A randomized double blind study |
title_full | Comparison of intubating conditions following administration of low-dose rocuronium or succinylcholine in adults: A randomized double blind study |
title_fullStr | Comparison of intubating conditions following administration of low-dose rocuronium or succinylcholine in adults: A randomized double blind study |
title_full_unstemmed | Comparison of intubating conditions following administration of low-dose rocuronium or succinylcholine in adults: A randomized double blind study |
title_short | Comparison of intubating conditions following administration of low-dose rocuronium or succinylcholine in adults: A randomized double blind study |
title_sort | comparison of intubating conditions following administration of low-dose rocuronium or succinylcholine in adults: a randomized double blind study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173439/ https://www.ncbi.nlm.nih.gov/pubmed/25885505 http://dx.doi.org/10.4103/0259-1162.103377 |
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