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Comparison of colloid preload versus coload under low dose spinal anesthesia for cesarean delivery
BACKGROUND: Although fluid bolus is considered as a conventional prophylactic measure to prevent spinal-induced hypotension; vasopressors are nevertheless required. Low dose spinal anesthetics could markedly reduce such episodes of hypotension, by minimizing sympathetic blockade. AIMS: We chose to c...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173561/ https://www.ncbi.nlm.nih.gov/pubmed/25885987 http://dx.doi.org/10.4103/0259-1162.123248 |
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author | Varshney, Rohit Jain, Gaurav |
author_facet | Varshney, Rohit Jain, Gaurav |
author_sort | Varshney, Rohit |
collection | PubMed |
description | BACKGROUND: Although fluid bolus is considered as a conventional prophylactic measure to prevent spinal-induced hypotension; vasopressors are nevertheless required. Low dose spinal anesthetics could markedly reduce such episodes of hypotension, by minimizing sympathetic blockade. AIMS: We chose to compare the relative efficacy of colloid preload versus coload under low dose spinal anesthesia, for elective cesarean delivery. SETTINGS AND DESIGN: A prospective, randomized, double-blinded study. MATERIALS AND METHODS: In total, 42 parturients were randomized to receive a preload (Group P) of hydroxyl ethyl starch (10 ml/kg) over 20 min before initiation of low dose spinal anesthesia (hyperbaric bupivacaine 5.5 mg with fentanyl 25 μg) or coload (Group C) of an identical fluid over 5 min, starting at the time of identification of cerebrospinal fluid. Our primary outcome included hemodynamic parameters and the incidence of hypotension. The neonatal outcome and side-effects were also monitored. STATISTICAL ANALYSIS: Mann-Whitney U test and Fisher's exact/Chi-square test, whichever appropriate. A P < 0.05 was considered to be significant. RESULTS: The incidence of hypotension was lower in Group P (10%) when compared with Group C (25%), though insignificant statistically. The hemodynamic parameters were better in Group P, though intergroup statistical differences were not observed. The time to the first episode of hypotension was longer in the Group P (17 min) as compared with Group C (14 min). No notable side-effects or adverse neonatal outcome was noted. CONCLUSION: Colloid preload has a clinical advantage over the coload strategy, in reducing hypotensive episodes under low dose spinal anesthesia. Preload is better under large hemodynamic fluctuations while coload is preferable for emergency scenarios. |
format | Online Article Text |
id | pubmed-4173561 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-41735612014-10-22 Comparison of colloid preload versus coload under low dose spinal anesthesia for cesarean delivery Varshney, Rohit Jain, Gaurav Anesth Essays Res Original Article BACKGROUND: Although fluid bolus is considered as a conventional prophylactic measure to prevent spinal-induced hypotension; vasopressors are nevertheless required. Low dose spinal anesthetics could markedly reduce such episodes of hypotension, by minimizing sympathetic blockade. AIMS: We chose to compare the relative efficacy of colloid preload versus coload under low dose spinal anesthesia, for elective cesarean delivery. SETTINGS AND DESIGN: A prospective, randomized, double-blinded study. MATERIALS AND METHODS: In total, 42 parturients were randomized to receive a preload (Group P) of hydroxyl ethyl starch (10 ml/kg) over 20 min before initiation of low dose spinal anesthesia (hyperbaric bupivacaine 5.5 mg with fentanyl 25 μg) or coload (Group C) of an identical fluid over 5 min, starting at the time of identification of cerebrospinal fluid. Our primary outcome included hemodynamic parameters and the incidence of hypotension. The neonatal outcome and side-effects were also monitored. STATISTICAL ANALYSIS: Mann-Whitney U test and Fisher's exact/Chi-square test, whichever appropriate. A P < 0.05 was considered to be significant. RESULTS: The incidence of hypotension was lower in Group P (10%) when compared with Group C (25%), though insignificant statistically. The hemodynamic parameters were better in Group P, though intergroup statistical differences were not observed. The time to the first episode of hypotension was longer in the Group P (17 min) as compared with Group C (14 min). No notable side-effects or adverse neonatal outcome was noted. CONCLUSION: Colloid preload has a clinical advantage over the coload strategy, in reducing hypotensive episodes under low dose spinal anesthesia. Preload is better under large hemodynamic fluctuations while coload is preferable for emergency scenarios. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC4173561/ /pubmed/25885987 http://dx.doi.org/10.4103/0259-1162.123248 Text en Copyright: © Anesthesia: Essays and Researches http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Varshney, Rohit Jain, Gaurav Comparison of colloid preload versus coload under low dose spinal anesthesia for cesarean delivery |
title | Comparison of colloid preload versus coload under low dose spinal anesthesia for cesarean delivery |
title_full | Comparison of colloid preload versus coload under low dose spinal anesthesia for cesarean delivery |
title_fullStr | Comparison of colloid preload versus coload under low dose spinal anesthesia for cesarean delivery |
title_full_unstemmed | Comparison of colloid preload versus coload under low dose spinal anesthesia for cesarean delivery |
title_short | Comparison of colloid preload versus coload under low dose spinal anesthesia for cesarean delivery |
title_sort | comparison of colloid preload versus coload under low dose spinal anesthesia for cesarean delivery |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173561/ https://www.ncbi.nlm.nih.gov/pubmed/25885987 http://dx.doi.org/10.4103/0259-1162.123248 |
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