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Refining the Balance of Attenuation and Immunogenicity of Respiratory Syncytial Virus by Targeted Codon Deoptimization of Virulence Genes

Respiratory syncytial virus (RSV) is the most important pathogen for lower respiratory tract illness in children for which there is no licensed vaccine. Live-attenuated RSV vaccines are the most clinically advanced in children, but achieving an optimal balance of attenuation and immunogenicity is ch...

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Detalles Bibliográficos
Autores principales:	Meng, Jia, Lee, Sujin, Hotard, Anne L., Moore, Martin L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Microbiology 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173764/ https://www.ncbi.nlm.nih.gov/pubmed/25249281 http://dx.doi.org/10.1128/mBio.01704-14

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