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Epigenetic regulation of cholesterol homeostasis

Although best known as a risk factor for cardiovascular disease, cholesterol is a vital component of all mammalian cells. In addition to key structural roles, cholesterol is a vital biochemical precursor for numerous biologically important compounds including oxysterols and bile acids, as well as ac...

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Detalles Bibliográficos
Autor principal: Meaney, Steve
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174035/
https://www.ncbi.nlm.nih.gov/pubmed/25309573
http://dx.doi.org/10.3389/fgene.2014.00311
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author Meaney, Steve
author_facet Meaney, Steve
author_sort Meaney, Steve
collection PubMed
description Although best known as a risk factor for cardiovascular disease, cholesterol is a vital component of all mammalian cells. In addition to key structural roles, cholesterol is a vital biochemical precursor for numerous biologically important compounds including oxysterols and bile acids, as well as acting as an activator of critical morphogenic systems (e.g., the Hedgehog system). A variety of sophisticated regulatory mechanisms interact to coordinate the overall level of cholesterol in cells, tissues and the entire organism. Accumulating evidence indicates that in additional to the more “traditional” regulatory schemes, cholesterol homeostasis is also under the control of epigenetic mechanisms such as histone acetylation and DNA methylation. The available evidence supporting a role for these mechanisms in the control of cholesterol synthesis, elimination, transport and storage are the focus of this review.
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spelling pubmed-41740352014-10-10 Epigenetic regulation of cholesterol homeostasis Meaney, Steve Front Genet Genetics Although best known as a risk factor for cardiovascular disease, cholesterol is a vital component of all mammalian cells. In addition to key structural roles, cholesterol is a vital biochemical precursor for numerous biologically important compounds including oxysterols and bile acids, as well as acting as an activator of critical morphogenic systems (e.g., the Hedgehog system). A variety of sophisticated regulatory mechanisms interact to coordinate the overall level of cholesterol in cells, tissues and the entire organism. Accumulating evidence indicates that in additional to the more “traditional” regulatory schemes, cholesterol homeostasis is also under the control of epigenetic mechanisms such as histone acetylation and DNA methylation. The available evidence supporting a role for these mechanisms in the control of cholesterol synthesis, elimination, transport and storage are the focus of this review. Frontiers Media S.A. 2014-09-24 /pmc/articles/PMC4174035/ /pubmed/25309573 http://dx.doi.org/10.3389/fgene.2014.00311 Text en Copyright © 2014 Meaney. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Meaney, Steve
Epigenetic regulation of cholesterol homeostasis
title Epigenetic regulation of cholesterol homeostasis
title_full Epigenetic regulation of cholesterol homeostasis
title_fullStr Epigenetic regulation of cholesterol homeostasis
title_full_unstemmed Epigenetic regulation of cholesterol homeostasis
title_short Epigenetic regulation of cholesterol homeostasis
title_sort epigenetic regulation of cholesterol homeostasis
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174035/
https://www.ncbi.nlm.nih.gov/pubmed/25309573
http://dx.doi.org/10.3389/fgene.2014.00311
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