Community-based recruitment of patients with COPD into clinical research

ABSTRACT: Identifying subjects for clinical trials is difficult and the evidence base for recruitment strategies is limited, particularly in the field of COPD. We compared the efficiency and patient characteristics of different community-based recruitment strategies during a non-commercial COPD tria...

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Autores principales: Brill, Simon E, El-Emir, Ethaar, Allinson, James P, Donaldson, Gavin C, Nazareth, Irwin, Wedzicha, Jadwiga A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2014
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174139/
https://www.ncbi.nlm.nih.gov/pubmed/24595667
http://dx.doi.org/10.1136/thoraxjnl-2014-205253
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author Brill, Simon E
El-Emir, Ethaar
Allinson, James P
Donaldson, Gavin C
Nazareth, Irwin
Wedzicha, Jadwiga A
author_facet Brill, Simon E
El-Emir, Ethaar
Allinson, James P
Donaldson, Gavin C
Nazareth, Irwin
Wedzicha, Jadwiga A
author_sort Brill, Simon E
collection PubMed
description ABSTRACT: Identifying subjects for clinical trials is difficult and the evidence base for recruitment strategies is limited, particularly in the field of COPD. We compared the efficiency and patient characteristics of different community-based recruitment strategies during a non-commercial COPD trial in the UK. Recruiting from general practice COPD registers was less efficient and identified patients with significantly milder disease than recruiting through pulmonary rehabilitation and patient groups. We report our experience and propose that pulmonary rehabilitation and patient groups may represent an enriched pool of COPD patients to recruit into clinical trials. TRIAL REGISTRATION NUMBER: EudraCT 2011-001063-43
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spelling pubmed-41741392014-10-02 Community-based recruitment of patients with COPD into clinical research Brill, Simon E El-Emir, Ethaar Allinson, James P Donaldson, Gavin C Nazareth, Irwin Wedzicha, Jadwiga A Thorax Research Letter ABSTRACT: Identifying subjects for clinical trials is difficult and the evidence base for recruitment strategies is limited, particularly in the field of COPD. We compared the efficiency and patient characteristics of different community-based recruitment strategies during a non-commercial COPD trial in the UK. Recruiting from general practice COPD registers was less efficient and identified patients with significantly milder disease than recruiting through pulmonary rehabilitation and patient groups. We report our experience and propose that pulmonary rehabilitation and patient groups may represent an enriched pool of COPD patients to recruit into clinical trials. TRIAL REGISTRATION NUMBER: EudraCT 2011-001063-43 BMJ Publishing Group 2014-10 2014-03-04 /pmc/articles/PMC4174139/ /pubmed/24595667 http://dx.doi.org/10.1136/thoraxjnl-2014-205253 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Research Letter
Brill, Simon E
El-Emir, Ethaar
Allinson, James P
Donaldson, Gavin C
Nazareth, Irwin
Wedzicha, Jadwiga A
Community-based recruitment of patients with COPD into clinical research
title Community-based recruitment of patients with COPD into clinical research
title_full Community-based recruitment of patients with COPD into clinical research
title_fullStr Community-based recruitment of patients with COPD into clinical research
title_full_unstemmed Community-based recruitment of patients with COPD into clinical research
title_short Community-based recruitment of patients with COPD into clinical research
title_sort community-based recruitment of patients with copd into clinical research
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174139/
https://www.ncbi.nlm.nih.gov/pubmed/24595667
http://dx.doi.org/10.1136/thoraxjnl-2014-205253
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