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Clinical Evidence for the Relationship between Nail Configuration and Mechanical Forces
SUMMARY: Mechanobiology is an emerging field of science that focuses on the way physical forces and changes in cell or tissue mechanics contribute to development, physiology, and disease. As nails are always exposed to physical stimulation, mechanical forces may have a particularly pronounced effect...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174141/ https://www.ncbi.nlm.nih.gov/pubmed/25289309 http://dx.doi.org/10.1097/GOX.0000000000000057 |
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author | Sano, Hitomi Ogawa, Rei |
author_facet | Sano, Hitomi Ogawa, Rei |
author_sort | Sano, Hitomi |
collection | PubMed |
description | SUMMARY: Mechanobiology is an emerging field of science that focuses on the way physical forces and changes in cell or tissue mechanics contribute to development, physiology, and disease. As nails are always exposed to physical stimulation, mechanical forces may have a particularly pronounced effect on nail configuration and could be involved in the development of nail deformities. However, the role of mechanobiology in nail configuration and deformities has rarely been assessed. This review describes what is currently understood regarding the effect of mechanical force on nail configuration and deformities. On the basis of these observations, we hypothesize that nails have an automatic curvature function that allows them to adapt to the daily upward mechanical forces. Under normal conditions, the upward daily mechanical force and the automatic curvature force are well balanced. However, an imbalance between these 2 forces may cause nail deformation. For example, pincer nails may be caused by the absence of upward mechanical forces or a genetic propensity increase in the automatic curvature force, whereas koilonychias may occur when the upward mechanical force exceeds the automatic curvature force, thereby causing the nail to curve outward. This hypothesis is a new concept that could aid the development of innovative methods to prevent and treat nail deformities. |
format | Online Article Text |
id | pubmed-4174141 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-41741412014-10-06 Clinical Evidence for the Relationship between Nail Configuration and Mechanical Forces Sano, Hitomi Ogawa, Rei Plast Reconstr Surg Glob Open Original Articles SUMMARY: Mechanobiology is an emerging field of science that focuses on the way physical forces and changes in cell or tissue mechanics contribute to development, physiology, and disease. As nails are always exposed to physical stimulation, mechanical forces may have a particularly pronounced effect on nail configuration and could be involved in the development of nail deformities. However, the role of mechanobiology in nail configuration and deformities has rarely been assessed. This review describes what is currently understood regarding the effect of mechanical force on nail configuration and deformities. On the basis of these observations, we hypothesize that nails have an automatic curvature function that allows them to adapt to the daily upward mechanical forces. Under normal conditions, the upward daily mechanical force and the automatic curvature force are well balanced. However, an imbalance between these 2 forces may cause nail deformation. For example, pincer nails may be caused by the absence of upward mechanical forces or a genetic propensity increase in the automatic curvature force, whereas koilonychias may occur when the upward mechanical force exceeds the automatic curvature force, thereby causing the nail to curve outward. This hypothesis is a new concept that could aid the development of innovative methods to prevent and treat nail deformities. Wolters Kluwer Health 2014-04-07 /pmc/articles/PMC4174141/ /pubmed/25289309 http://dx.doi.org/10.1097/GOX.0000000000000057 Text en Copyright © 2013 The Authors. Published by Lippincott Williams & Wilkins on behalf of The American Society of Plastic Surgeons. PRS Global Open is a publication of the American Society of Plastic Surgeons. http://creativecommons.org/licenses/by-nc-nd/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivitives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. |
spellingShingle | Original Articles Sano, Hitomi Ogawa, Rei Clinical Evidence for the Relationship between Nail Configuration and Mechanical Forces |
title | Clinical Evidence for the Relationship between Nail Configuration and Mechanical Forces |
title_full | Clinical Evidence for the Relationship between Nail Configuration and Mechanical Forces |
title_fullStr | Clinical Evidence for the Relationship between Nail Configuration and Mechanical Forces |
title_full_unstemmed | Clinical Evidence for the Relationship between Nail Configuration and Mechanical Forces |
title_short | Clinical Evidence for the Relationship between Nail Configuration and Mechanical Forces |
title_sort | clinical evidence for the relationship between nail configuration and mechanical forces |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174141/ https://www.ncbi.nlm.nih.gov/pubmed/25289309 http://dx.doi.org/10.1097/GOX.0000000000000057 |
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