Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice

Accumulation of β-amyloid (Aβ) in the brain is essential to Alzheimer’s disease (AD) pathogenesis. Carriers of the apolipoprotein E (APOE) ε4 allele demonstrate greatly increased AD risk and enhanced brain Aβ deposition. In contrast, APOE ε2 allele carries show reduced AD risk, later age of disease...

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Detalles Bibliográficos
Autores principales: Pankiewicz, Joanna E, Guridi, Maitea, Kim, Jungsu, Asuni, Ayodeji A, Sanchez, Sandrine, Sullivan, Patrick M, Holtzman, David M, Sadowski, Martin J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174325/
https://www.ncbi.nlm.nih.gov/pubmed/24972680
http://dx.doi.org/10.1186/s40478-014-0075-0

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