Characterisation of a K390R ITK Kinase Dead Transgenic Mouse – Implications for ITK as a Therapeutic Target

Interleukin-2 inducible tyrosine kinase (ITK) is expressed in T cells and plays a critical role in signalling through the T cell receptor. Evidence, mainly from knockout mice, has suggested that ITK plays a particularly important function in Th2 cells and this has prompted significant efforts to dis...

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Detalles Bibliográficos
Autores principales: Deakin, Angela, Duddy, Graham, Wilson, Steve, Harrison, Steve, Latcham, Judi, Fulleylove, Mick, Fung, Sylvia, Smith, Jason, Pedrick, Mike, McKevitt, Tom, Felton, Leigh, Morley, Joanne, Quint, Diana, Fattah, Dilniya, Hayes, Brian, Gough, Jade, Solari, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174519/
https://www.ncbi.nlm.nih.gov/pubmed/25250764
http://dx.doi.org/10.1371/journal.pone.0107490

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