Cargando…

Menopause Analytical Hormonal Correlate Outcome Study (MAHCOS) and the Association to Brain Electrophysiology (P300) in a Clinical Setting

Various studies have demonstrated that increased leptin levels and obesity are inversely related to cognitive decline in menopausal women. It is hypothesized that adiposity is inversely correlated with cognitive decline, as women with increased weight are less vulnerable to diminishing cognition. Ho...

Descripción completa

Detalles Bibliográficos
Autores principales: Braverman, Eric R., Han, David, Oscar-Berman, Marlene, Karikh, Tatiana, Truesdell, Courtney, Dushaj, Kristina, Kreuk, Florian, Li, Mona, Stratton, Danielle, Blum, Kenneth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174522/
https://www.ncbi.nlm.nih.gov/pubmed/25251414
http://dx.doi.org/10.1371/journal.pone.0105048
_version_ 1782336356011212800
author Braverman, Eric R.
Han, David
Oscar-Berman, Marlene
Karikh, Tatiana
Truesdell, Courtney
Dushaj, Kristina
Kreuk, Florian
Li, Mona
Stratton, Danielle
Blum, Kenneth
author_facet Braverman, Eric R.
Han, David
Oscar-Berman, Marlene
Karikh, Tatiana
Truesdell, Courtney
Dushaj, Kristina
Kreuk, Florian
Li, Mona
Stratton, Danielle
Blum, Kenneth
author_sort Braverman, Eric R.
collection PubMed
description Various studies have demonstrated that increased leptin levels and obesity are inversely related to cognitive decline in menopausal women. It is hypothesized that adiposity is inversely correlated with cognitive decline, as women with increased weight are less vulnerable to diminishing cognition. However, it is increasingly observed that menopausal women, even with increased adiposity, experience significant cognitive decline. Positron emission tomography (PET) has been used to analyze cognitive function and processing in menopausal women. Evoked potentials (P300) and neurophysiologic tests have validated brain metabolism in cognitively impaired patients. Post-hoc analyses of 796 female patients entering PATH Medical Clinic, between January 4, 2009 and February 24, 2013, were performed as part of the “Menopause Analytical Hormonal Correlate Outcome Study” (MAHCOS). Patient age range was 39–76 years (46.7±0.2). P300 latency and amplitude correlated with a number of hormones: follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol, estrone, estriol, DHEA, pregnenolone, progesterone, free and total testosterone, thyroid stimulating hormone (TSH), Vitamins D 1.25 and D 25OH, leptin, and insulin-like growth factor-binding protein 3 (IGF-BP3). Corrected statistics did not reveal significant associations with P300 latency or amplitude for these hormones except for leptin plasma levels. However, factor analysis showed that FSH and LH clustered together with Vitamin D1.25 and Vitamin D25OH, P300 latency (not amplitude), and log leptin were found to be associated in the same cluster. Utilizing regression analysis, once age adjusted, leptin was the only significant predictor for latency or speed (p = 0.03) with an effect size of 0.23. Higher plasma leptin levels were associated with abnormal P300 speed (OR = 0.98). Our findings show a significant relationship of higher plasma leptin levels, potentially due to leptin resistance, and prolonged P300 latency. This suggests leptin resistance may delay electrophysiological processing of memory and attention, which appears to be the first of such an association.
format Online
Article
Text
id pubmed-4174522
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-41745222014-10-02 Menopause Analytical Hormonal Correlate Outcome Study (MAHCOS) and the Association to Brain Electrophysiology (P300) in a Clinical Setting Braverman, Eric R. Han, David Oscar-Berman, Marlene Karikh, Tatiana Truesdell, Courtney Dushaj, Kristina Kreuk, Florian Li, Mona Stratton, Danielle Blum, Kenneth PLoS One Research Article Various studies have demonstrated that increased leptin levels and obesity are inversely related to cognitive decline in menopausal women. It is hypothesized that adiposity is inversely correlated with cognitive decline, as women with increased weight are less vulnerable to diminishing cognition. However, it is increasingly observed that menopausal women, even with increased adiposity, experience significant cognitive decline. Positron emission tomography (PET) has been used to analyze cognitive function and processing in menopausal women. Evoked potentials (P300) and neurophysiologic tests have validated brain metabolism in cognitively impaired patients. Post-hoc analyses of 796 female patients entering PATH Medical Clinic, between January 4, 2009 and February 24, 2013, were performed as part of the “Menopause Analytical Hormonal Correlate Outcome Study” (MAHCOS). Patient age range was 39–76 years (46.7±0.2). P300 latency and amplitude correlated with a number of hormones: follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol, estrone, estriol, DHEA, pregnenolone, progesterone, free and total testosterone, thyroid stimulating hormone (TSH), Vitamins D 1.25 and D 25OH, leptin, and insulin-like growth factor-binding protein 3 (IGF-BP3). Corrected statistics did not reveal significant associations with P300 latency or amplitude for these hormones except for leptin plasma levels. However, factor analysis showed that FSH and LH clustered together with Vitamin D1.25 and Vitamin D25OH, P300 latency (not amplitude), and log leptin were found to be associated in the same cluster. Utilizing regression analysis, once age adjusted, leptin was the only significant predictor for latency or speed (p = 0.03) with an effect size of 0.23. Higher plasma leptin levels were associated with abnormal P300 speed (OR = 0.98). Our findings show a significant relationship of higher plasma leptin levels, potentially due to leptin resistance, and prolonged P300 latency. This suggests leptin resistance may delay electrophysiological processing of memory and attention, which appears to be the first of such an association. Public Library of Science 2014-09-24 /pmc/articles/PMC4174522/ /pubmed/25251414 http://dx.doi.org/10.1371/journal.pone.0105048 Text en © 2014 Braverman et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Braverman, Eric R.
Han, David
Oscar-Berman, Marlene
Karikh, Tatiana
Truesdell, Courtney
Dushaj, Kristina
Kreuk, Florian
Li, Mona
Stratton, Danielle
Blum, Kenneth
Menopause Analytical Hormonal Correlate Outcome Study (MAHCOS) and the Association to Brain Electrophysiology (P300) in a Clinical Setting
title Menopause Analytical Hormonal Correlate Outcome Study (MAHCOS) and the Association to Brain Electrophysiology (P300) in a Clinical Setting
title_full Menopause Analytical Hormonal Correlate Outcome Study (MAHCOS) and the Association to Brain Electrophysiology (P300) in a Clinical Setting
title_fullStr Menopause Analytical Hormonal Correlate Outcome Study (MAHCOS) and the Association to Brain Electrophysiology (P300) in a Clinical Setting
title_full_unstemmed Menopause Analytical Hormonal Correlate Outcome Study (MAHCOS) and the Association to Brain Electrophysiology (P300) in a Clinical Setting
title_short Menopause Analytical Hormonal Correlate Outcome Study (MAHCOS) and the Association to Brain Electrophysiology (P300) in a Clinical Setting
title_sort menopause analytical hormonal correlate outcome study (mahcos) and the association to brain electrophysiology (p300) in a clinical setting
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174522/
https://www.ncbi.nlm.nih.gov/pubmed/25251414
http://dx.doi.org/10.1371/journal.pone.0105048
work_keys_str_mv AT bravermanericr menopauseanalyticalhormonalcorrelateoutcomestudymahcosandtheassociationtobrainelectrophysiologyp300inaclinicalsetting
AT handavid menopauseanalyticalhormonalcorrelateoutcomestudymahcosandtheassociationtobrainelectrophysiologyp300inaclinicalsetting
AT oscarbermanmarlene menopauseanalyticalhormonalcorrelateoutcomestudymahcosandtheassociationtobrainelectrophysiologyp300inaclinicalsetting
AT karikhtatiana menopauseanalyticalhormonalcorrelateoutcomestudymahcosandtheassociationtobrainelectrophysiologyp300inaclinicalsetting
AT truesdellcourtney menopauseanalyticalhormonalcorrelateoutcomestudymahcosandtheassociationtobrainelectrophysiologyp300inaclinicalsetting
AT dushajkristina menopauseanalyticalhormonalcorrelateoutcomestudymahcosandtheassociationtobrainelectrophysiologyp300inaclinicalsetting
AT kreukflorian menopauseanalyticalhormonalcorrelateoutcomestudymahcosandtheassociationtobrainelectrophysiologyp300inaclinicalsetting
AT limona menopauseanalyticalhormonalcorrelateoutcomestudymahcosandtheassociationtobrainelectrophysiologyp300inaclinicalsetting
AT strattondanielle menopauseanalyticalhormonalcorrelateoutcomestudymahcosandtheassociationtobrainelectrophysiologyp300inaclinicalsetting
AT blumkenneth menopauseanalyticalhormonalcorrelateoutcomestudymahcosandtheassociationtobrainelectrophysiologyp300inaclinicalsetting