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Modelling of a targeted nanotherapeutic ‘stroma’ to deliver the cytokine LIF, or XAV939, a potent inhibitor of Wnt–β-catenin signalling, for use in human fetal dopaminergic grafts in Parkinson’s disease

The endogenous reparative capacity of the adult human brain is low, and chronic neurodegenerative disorders of the central nervous system represent one of the greatest areas of unmet clinical need in the developing world. Novel therapeutic strategies to treat them include: (i) growth factor delivery...

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Detalles Bibliográficos
Autores principales:	Zhao, Jing-Wei, Dyson, Sean C., Kriegel, Christina, Tyers, Pam, He, Xiaoling, Fahmy, Tarek M., Metcalfe, Su M., Barker, Roger A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Limited 2014
Materias:	Resource Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174530/ https://www.ncbi.nlm.nih.gov/pubmed/25085990 http://dx.doi.org/10.1242/dmm.015859

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