Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states

The Notch signaling pathway consists of multiple types of receptors and ligands, whose interactions can be tuned by Fringe glycosyltransferases. A major challenge is to determine how these components control the specificity and directionality of Notch signaling in developmental contexts. Here, we an...

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Detalles Bibliográficos
Autores principales: LeBon, Lauren, Lee, Tom V, Sprinzak, David, Jafar-Nejad, Hamed, Elowitz, Michael B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Developmental Biology and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174579/
https://www.ncbi.nlm.nih.gov/pubmed/25255098
http://dx.doi.org/10.7554/eLife.02950

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174579/
https://www.ncbi.nlm.nih.gov/pubmed/25255098
http://dx.doi.org/10.7554/eLife.02950

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