Carbimazole inhibits TNF-α expression in Fat-induced hypothyroidism

The effect of the carbimazole on expression of tumor necrosis factor (TNF-α) in liver, was investigated in an experimental model of high fat diet (HFD) induced obesity. The HFD (orally given for 4 months) induced TNF-α in liver tissue along with raised serum triglyceride (TG), cholesterol and high T...

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Autores principales: Tripathi, Yamani Bhusan, Pandey, Nidhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174658/
https://www.ncbi.nlm.nih.gov/pubmed/25258706
http://dx.doi.org/10.1186/s40200-014-0083-4
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author Tripathi, Yamani Bhusan
Pandey, Nidhi
author_facet Tripathi, Yamani Bhusan
Pandey, Nidhi
author_sort Tripathi, Yamani Bhusan
collection PubMed
description The effect of the carbimazole on expression of tumor necrosis factor (TNF-α) in liver, was investigated in an experimental model of high fat diet (HFD) induced obesity. The HFD (orally given for 4 months) induced TNF-α in liver tissue along with raised serum triglyceride (TG), cholesterol and high TSH (62%). In carbimazole (1 mg/100 gbw) treatment, the induction of TNF-α was significantly inhibited, without affecting other parameters. It also improved the liver function, which was raised due to HFD in experimental control rats.
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spelling pubmed-41746582014-09-26 Carbimazole inhibits TNF-α expression in Fat-induced hypothyroidism Tripathi, Yamani Bhusan Pandey, Nidhi J Diabetes Metab Disord Letter to the Editor The effect of the carbimazole on expression of tumor necrosis factor (TNF-α) in liver, was investigated in an experimental model of high fat diet (HFD) induced obesity. The HFD (orally given for 4 months) induced TNF-α in liver tissue along with raised serum triglyceride (TG), cholesterol and high TSH (62%). In carbimazole (1 mg/100 gbw) treatment, the induction of TNF-α was significantly inhibited, without affecting other parameters. It also improved the liver function, which was raised due to HFD in experimental control rats. BioMed Central 2014-08-21 /pmc/articles/PMC4174658/ /pubmed/25258706 http://dx.doi.org/10.1186/s40200-014-0083-4 Text en © Tripathi and Pandey; licensee BioMed Central Ltd. 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter to the Editor
Tripathi, Yamani Bhusan
Pandey, Nidhi
Carbimazole inhibits TNF-α expression in Fat-induced hypothyroidism
title Carbimazole inhibits TNF-α expression in Fat-induced hypothyroidism
title_full Carbimazole inhibits TNF-α expression in Fat-induced hypothyroidism
title_fullStr Carbimazole inhibits TNF-α expression in Fat-induced hypothyroidism
title_full_unstemmed Carbimazole inhibits TNF-α expression in Fat-induced hypothyroidism
title_short Carbimazole inhibits TNF-α expression in Fat-induced hypothyroidism
title_sort carbimazole inhibits tnf-α expression in fat-induced hypothyroidism
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174658/
https://www.ncbi.nlm.nih.gov/pubmed/25258706
http://dx.doi.org/10.1186/s40200-014-0083-4
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