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Distribution of nitric oxide-producing cells along spinal cord in urodeles
Nitric oxide is a unique neurotransmitter, which participates in many physiological and pathological processes in the organism. There are little data about the neuronal nitric oxide synthase immunoreactivity in the spinal cord of amphibians. In this respect, the present study aims to investigate the...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174862/ https://www.ncbi.nlm.nih.gov/pubmed/25309330 http://dx.doi.org/10.3389/fncel.2014.00299 |
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author | Mahmoud, Mayada A. Fahmy, Gehan H. Moftah, Marie Z. Sabry, Ismail |
author_facet | Mahmoud, Mayada A. Fahmy, Gehan H. Moftah, Marie Z. Sabry, Ismail |
author_sort | Mahmoud, Mayada A. |
collection | PubMed |
description | Nitric oxide is a unique neurotransmitter, which participates in many physiological and pathological processes in the organism. There are little data about the neuronal nitric oxide synthase immunoreactivity in the spinal cord of amphibians. In this respect, the present study aims to investigate the distribution of nitric oxide producing cells in the spinal cord of urodele and to find out the possibility of a functional locomotory role to this neurotransmitter. The results of the present study demonstrate a specific pattern of NADPH-d labeling in the selected amphibian model throughout the spinal cord length as NADPH-d-producing cells and fibers were present in almost all segments of the spinal cord of the salamander investigated. However, their number, cytological characteristics and labeling intensity varied significantly. It was noticed that the NO-producing cells (NO-PC) were accumulated in the ventral side of certain segments in the spinal cord corresponding to the brachial and sacral plexuses. In addition, the number of NO-PC was found to be increased also at the beginning of the tail and this could be due to the fact that salamanders are tetrapods having bimodal locomotion, namely swimming and walking. |
format | Online Article Text |
id | pubmed-4174862 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-41748622014-10-10 Distribution of nitric oxide-producing cells along spinal cord in urodeles Mahmoud, Mayada A. Fahmy, Gehan H. Moftah, Marie Z. Sabry, Ismail Front Cell Neurosci Neuroscience Nitric oxide is a unique neurotransmitter, which participates in many physiological and pathological processes in the organism. There are little data about the neuronal nitric oxide synthase immunoreactivity in the spinal cord of amphibians. In this respect, the present study aims to investigate the distribution of nitric oxide producing cells in the spinal cord of urodele and to find out the possibility of a functional locomotory role to this neurotransmitter. The results of the present study demonstrate a specific pattern of NADPH-d labeling in the selected amphibian model throughout the spinal cord length as NADPH-d-producing cells and fibers were present in almost all segments of the spinal cord of the salamander investigated. However, their number, cytological characteristics and labeling intensity varied significantly. It was noticed that the NO-producing cells (NO-PC) were accumulated in the ventral side of certain segments in the spinal cord corresponding to the brachial and sacral plexuses. In addition, the number of NO-PC was found to be increased also at the beginning of the tail and this could be due to the fact that salamanders are tetrapods having bimodal locomotion, namely swimming and walking. Frontiers Media S.A. 2014-09-25 /pmc/articles/PMC4174862/ /pubmed/25309330 http://dx.doi.org/10.3389/fncel.2014.00299 Text en Copyright © 2014 Mahmoud, Fahmy, Moftah and Sabry. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Mahmoud, Mayada A. Fahmy, Gehan H. Moftah, Marie Z. Sabry, Ismail Distribution of nitric oxide-producing cells along spinal cord in urodeles |
title | Distribution of nitric oxide-producing cells along spinal cord in urodeles |
title_full | Distribution of nitric oxide-producing cells along spinal cord in urodeles |
title_fullStr | Distribution of nitric oxide-producing cells along spinal cord in urodeles |
title_full_unstemmed | Distribution of nitric oxide-producing cells along spinal cord in urodeles |
title_short | Distribution of nitric oxide-producing cells along spinal cord in urodeles |
title_sort | distribution of nitric oxide-producing cells along spinal cord in urodeles |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174862/ https://www.ncbi.nlm.nih.gov/pubmed/25309330 http://dx.doi.org/10.3389/fncel.2014.00299 |
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