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A Comparative Study between Olanzapine and Risperidone Regarding Drug-Induced Electrocardiographic Changes
Introduction. Among atypical antipsychotics, none has been linked to torsade de pointes. In the present study, the electrocardiographic changes induced by olanzapine have been compared with risperidone. Method and Materials. 268 patients were entered into an open study for random assignment to olanz...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174968/ https://www.ncbi.nlm.nih.gov/pubmed/25276418 http://dx.doi.org/10.1155/2014/637016 |
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author | Shoja Shafti, Saeed Fallah Jahromi, Parisa |
author_facet | Shoja Shafti, Saeed Fallah Jahromi, Parisa |
author_sort | Shoja Shafti, Saeed |
collection | PubMed |
description | Introduction. Among atypical antipsychotics, none has been linked to torsade de pointes. In the present study, the electrocardiographic changes induced by olanzapine have been compared with risperidone. Method and Materials. 268 patients were entered into an open study for random assignment to olanzapine or risperidone. ECG was taken at baseline and at the end of the treatment. The parameters that had been assessed included Q-T interval (corrected = Q-Tc) and other related parameters. Correction of the observed Q-T interval was done according to Frederica's formula (QTcF). Results. While 14.86% and 25% of the cases in the olanzapine group showed prolongation and shortening of QTcF, respectively, comparable changes in the risperidone group were restricted to its prolongation (32.5%). Comparison of means between baseline QTcF of risperidone group versus its posttreatment measurement showed a significant increment (P = 0.02). Also, the quantity of cases with shortening of QTcF in the olanzapine group was significantly more than its opposite (P = 0.02). Conclusion. Comparable propensity of olanzapine and risperidone for induction of electrocardiographic changes demands adequate cautiousness by clinicians, particularly with respect to shortening of Q-T interval, which was mainly noticeable in the olanzapine group. |
format | Online Article Text |
id | pubmed-4174968 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41749682014-09-30 A Comparative Study between Olanzapine and Risperidone Regarding Drug-Induced Electrocardiographic Changes Shoja Shafti, Saeed Fallah Jahromi, Parisa Cardiovasc Psychiatry Neurol Clinical Study Introduction. Among atypical antipsychotics, none has been linked to torsade de pointes. In the present study, the electrocardiographic changes induced by olanzapine have been compared with risperidone. Method and Materials. 268 patients were entered into an open study for random assignment to olanzapine or risperidone. ECG was taken at baseline and at the end of the treatment. The parameters that had been assessed included Q-T interval (corrected = Q-Tc) and other related parameters. Correction of the observed Q-T interval was done according to Frederica's formula (QTcF). Results. While 14.86% and 25% of the cases in the olanzapine group showed prolongation and shortening of QTcF, respectively, comparable changes in the risperidone group were restricted to its prolongation (32.5%). Comparison of means between baseline QTcF of risperidone group versus its posttreatment measurement showed a significant increment (P = 0.02). Also, the quantity of cases with shortening of QTcF in the olanzapine group was significantly more than its opposite (P = 0.02). Conclusion. Comparable propensity of olanzapine and risperidone for induction of electrocardiographic changes demands adequate cautiousness by clinicians, particularly with respect to shortening of Q-T interval, which was mainly noticeable in the olanzapine group. Hindawi Publishing Corporation 2014 2014-09-09 /pmc/articles/PMC4174968/ /pubmed/25276418 http://dx.doi.org/10.1155/2014/637016 Text en Copyright © 2014 S. Shoja Shafti and P. Fallah Jahromi. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Shoja Shafti, Saeed Fallah Jahromi, Parisa A Comparative Study between Olanzapine and Risperidone Regarding Drug-Induced Electrocardiographic Changes |
title | A Comparative Study between Olanzapine and Risperidone Regarding Drug-Induced Electrocardiographic Changes |
title_full | A Comparative Study between Olanzapine and Risperidone Regarding Drug-Induced Electrocardiographic Changes |
title_fullStr | A Comparative Study between Olanzapine and Risperidone Regarding Drug-Induced Electrocardiographic Changes |
title_full_unstemmed | A Comparative Study between Olanzapine and Risperidone Regarding Drug-Induced Electrocardiographic Changes |
title_short | A Comparative Study between Olanzapine and Risperidone Regarding Drug-Induced Electrocardiographic Changes |
title_sort | comparative study between olanzapine and risperidone regarding drug-induced electrocardiographic changes |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174968/ https://www.ncbi.nlm.nih.gov/pubmed/25276418 http://dx.doi.org/10.1155/2014/637016 |
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