Design, Synthesis, and Evaluation of Nonretinoid Retinol Binding Protein 4 Antagonists for the Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease

[Image: see text] Accumulation of lipofuscin in the retina is associated with pathogenesis of atrophic age-related macular degeneration and Stargardt disease. Lipofuscin bisretinoids (exemplified by N-retinylidene-N-retinylethanolamine) seem to mediate lipofuscin toxicity. Synthesis of lipofuscin bi...

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Detalles Bibliográficos
Autores principales: Cioffi, Christopher L., Dobri, Nicoleta, Freeman, Emily E., Conlon, Michael P., Chen, Ping, Stafford, Douglas G., Schwarz, Daniel M. C., Golden, Kathy C., Zhu, Lei, Kitchen, Douglas B., Barnes, Keith D., Racz, Boglarka, Qin, Qiong, Michelotti, Enrique, Cywin, Charles L., Martin, William H., Pearson, Paul G., Johnson, Graham, Petrukhin, Konstantin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174998/
https://www.ncbi.nlm.nih.gov/pubmed/25210858
http://dx.doi.org/10.1021/jm5010013

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