Calcium Transients Closely Reflect Prolonged Action Potentials in iPSC Models of Inherited Cardiac Arrhythmia

Long-QT syndrome mutations can cause syncope and sudden death by prolonging the cardiac action potential (AP). Ion channels affected by mutations are various, and the influences of cellular calcium cycling on LQTS cardiac events are unknown. To better understand LQTS arrhythmias, we performed curren...

Descripción completa

Detalles Bibliográficos
Autores principales: Spencer, C. Ian, Baba, Shiro, Nakamura, Kenta, Hua, Ethan A., Sears, Marie A.F., Fu, Chi-cheng, Zhang, Jianhua, Balijepalli, Sadguna, Tomoda, Kiichiro, Hayashi, Yohei, Lizarraga, Paweena, Wojciak, Julianne, Scheinman, Melvin M., Aalto-Setälä, Katriina, Makielski, Jonathan C., January, Craig T., Healy, Kevin E., Kamp, Timothy J., Yamanaka, Shinya, Conklin, Bruce R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175159/
https://www.ncbi.nlm.nih.gov/pubmed/25254341
http://dx.doi.org/10.1016/j.stemcr.2014.06.003

Ejemplares similares

Ejemplares similares