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Maternal Aldehyde Elimination during Pregnancy Preserves the Fetal Genome

Maternal metabolism provides essential nutrients to enable embryonic development. However, both mother and embryo produce reactive metabolites that can damage DNA. Here we discover how the embryo is protected from these genotoxins. Pregnant mice lacking Aldh2, a key enzyme that detoxifies reactive a...

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Detalles Bibliográficos
Autores principales:	Oberbeck, Nina, Langevin, Frédéric, King, Gareth, de Wind, Niels, Crossan, Gerry P., Patel, Ketan J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175174/ https://www.ncbi.nlm.nih.gov/pubmed/25155611 http://dx.doi.org/10.1016/j.molcel.2014.07.010

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