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Leydig cell tumors of the testis: a case report

BACKGROUND: Leydig cell tumors are the most common non-germ cell gonadal tumors with apparent increased incidence in the last few years. They are usually benign tumors. We report a case of Leydig cell tumor of testis in a patient presenting atypical features. CASE PRESENTATION: A 29-year-old Caucasi...

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Autor principal: Gheorghisan-Galateanu, Ancuta Augustina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175283/
https://www.ncbi.nlm.nih.gov/pubmed/25230718
http://dx.doi.org/10.1186/1756-0500-7-656
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author Gheorghisan-Galateanu, Ancuta Augustina
author_facet Gheorghisan-Galateanu, Ancuta Augustina
author_sort Gheorghisan-Galateanu, Ancuta Augustina
collection PubMed
description BACKGROUND: Leydig cell tumors are the most common non-germ cell gonadal tumors with apparent increased incidence in the last few years. They are usually benign tumors. We report a case of Leydig cell tumor of testis in a patient presenting atypical features. CASE PRESENTATION: A 29-year-old Caucasian man, born with right cryptorchidism, corrected without medical treatment before the age of two years, was diagnosed with Leydig cell tumor. Two years after diagnosis was identified moderately elevated estradiol serum level, in the context of a significant overweight, hormonal changes which had maintained after unilateral orchiectomy and after the patient's return to normal weight. Four years after unilateral orchiectomy, elevated value of estradiol persisted and subdiaphragmatic micro lymphadenopathy was observed. CONCLUSIONS: Despite the favorable evolution of the patient four years after unilateral orchiectomy, long-term follow-up is necessary to exclude recurrence or metastasis to the testis. The endocrine profile and imaging investigations need to be repeated periodically. The changes in the hormonal assay and any new aspects on computed tomography scan can be used as a marker of tumor recurrence and require careful screening and the correct therapeutic decisions.
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spelling pubmed-41752832014-09-27 Leydig cell tumors of the testis: a case report Gheorghisan-Galateanu, Ancuta Augustina BMC Res Notes Case Report BACKGROUND: Leydig cell tumors are the most common non-germ cell gonadal tumors with apparent increased incidence in the last few years. They are usually benign tumors. We report a case of Leydig cell tumor of testis in a patient presenting atypical features. CASE PRESENTATION: A 29-year-old Caucasian man, born with right cryptorchidism, corrected without medical treatment before the age of two years, was diagnosed with Leydig cell tumor. Two years after diagnosis was identified moderately elevated estradiol serum level, in the context of a significant overweight, hormonal changes which had maintained after unilateral orchiectomy and after the patient's return to normal weight. Four years after unilateral orchiectomy, elevated value of estradiol persisted and subdiaphragmatic micro lymphadenopathy was observed. CONCLUSIONS: Despite the favorable evolution of the patient four years after unilateral orchiectomy, long-term follow-up is necessary to exclude recurrence or metastasis to the testis. The endocrine profile and imaging investigations need to be repeated periodically. The changes in the hormonal assay and any new aspects on computed tomography scan can be used as a marker of tumor recurrence and require careful screening and the correct therapeutic decisions. BioMed Central 2014-09-18 /pmc/articles/PMC4175283/ /pubmed/25230718 http://dx.doi.org/10.1186/1756-0500-7-656 Text en © Gheorghisan-Galateanu; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Gheorghisan-Galateanu, Ancuta Augustina
Leydig cell tumors of the testis: a case report
title Leydig cell tumors of the testis: a case report
title_full Leydig cell tumors of the testis: a case report
title_fullStr Leydig cell tumors of the testis: a case report
title_full_unstemmed Leydig cell tumors of the testis: a case report
title_short Leydig cell tumors of the testis: a case report
title_sort leydig cell tumors of the testis: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175283/
https://www.ncbi.nlm.nih.gov/pubmed/25230718
http://dx.doi.org/10.1186/1756-0500-7-656
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