Cargando…

Distinguishing Closely Related Amyloid Precursors Using an RNA Aptamer

Although amyloid fibrils assembled in vitro commonly involve a single protein, fibrils formed in vivo can contain multiple protein sequences. The amyloidogenic protein human β(2)-microglobulin (hβ(2)m) can co-polymerize with its N-terminally truncated variant (ΔN6) in vitro to form hetero-polymeric...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sarell, Claire J., Karamanos, Theodoros K., White, Simon J., Bunka, David H. J., Kalverda, Arnout P., Thompson, Gary S., Barker, Amy M., Stockley, Peter G., Radford, Sheena E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2014
Materias:	Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175327/ https://www.ncbi.nlm.nih.gov/pubmed/25100729 http://dx.doi.org/10.1074/jbc.M114.595066

Ejemplares similares

Structural mapping of oligomeric intermediates in an amyloid assembly pathway
por: Karamanos, Theodoros K, et al.
Publicado: (2019)

Mechanisms of amyloid formation revealed by solution NMR
por: Karamanos, Theodoros K., et al.
Publicado: (2015)

Visualization of Transient Protein-Protein Interactions that Promote or Inhibit Amyloid Assembly
por: Karamanos, Theodoros K., et al.
Publicado: (2014)

Expanding the Repertoire of Amyloid Polymorphs by Co-polymerization of Related Protein Precursors
por: Sarell, Claire J., et al.
Publicado: (2013)

Production and Characterization of RNA Aptamers Specific for Amyloid Fibril Epitopes
por: Bunka, David H.J., et al.
Publicado: (2020)

Generating Ensembles of Dynamic Misfolding Proteins
por: Karamanos, Theodoros K., et al.
Publicado: (2022)

Assessing the causes and consequences of co-polymerization in amyloid formation
por: Sarell, Claire J, et al.
Publicado: (2013)

Conformational Conversion during Amyloid Formation at Atomic Resolution
por: Eichner, Timo, et al.
Publicado: (2011)

Characterization of RNA aptamers that disrupt the RUNX1–CBFβ/DNA complex
por: Barton, Jenny L., et al.
Publicado: (2009)

A Population Shift between Sparsely Populated Folding Intermediates Determines Amyloidogenicity
por: Karamanos, Theodoros K., et al.
Publicado: (2016)

Extracellular matrix components modulate different stages in β(2)-microglobulin amyloid formation
por: Benseny-Cases, Núria, et al.
Publicado: (2019)

Interaction of the Molecular Chaperone DNAJB6 with Growing Amyloid-beta 42 (Aβ42) Aggregates Leads to Sub-stoichiometric Inhibition of Amyloid Formation
por: Månsson, Cecilia, et al.
Publicado: (2014)

Identification of a Compound That Disrupts Binding of Amyloid-β to the Prion Protein Using a Novel Fluorescence-based Assay
por: Risse, Emmanuel, et al.
Publicado: (2015)

Visualizing and trapping transient oligomers in amyloid assembly pathways
por: Cawood, Emma E., et al.
Publicado: (2021)

A Na(+) leak channel cloned from Trichoplax adhaerens extends extracellular pH and Ca(2+) sensing for the DEG/ENaC family close to the base of Metazoa
por: Elkhatib, Wassim, et al.
Publicado: (2019)

Structural modeling of an outer membrane electron conduit from a metal-reducing bacterium suggests electron transfer via periplasmic redox partners
por: Edwards, Marcus J., et al.
Publicado: (2018)

(1)H NMR studies distinguish the water soluble metabolomic profiles of untransformed and RAS-transformed cells
por: Marks, Vered, et al.
Publicado: (2016)

Conformational Properties of the Unfolded State of Im7 in Nondenaturing Conditions
por: Pashley, Clare L., et al.
Publicado: (2012)

Crossroads between copper ions and amyloid formation in Parkinson’s disease
por: Wittung-Stafshede, Pernilla
Publicado: (2022)

Identification of a novel site of interaction between ataxin-3 and the amyloid aggregation inhibitor polyglutamine binding peptide 1
por: Knight, Patrick D, et al.
Publicado: (2017)

The Photoinitiated Reaction Pathway of Full-length Cyanobacteriochrome Tlr0924 Monitored Over 12 Orders of Magnitude
por: Hauck, Anna F. E., et al.
Publicado: (2014)

Small Substrate Transport and Mechanism of a Molybdate ATP Binding Cassette Transporter in a Lipid Environment
por: Rice, Austin J., et al.
Publicado: (2014)

The Intracellular Amino Terminus Plays a Dominant Role in Desensitization of ATP-gated P2X Receptor Ion Channels
por: Allsopp, Rebecca C., et al.
Publicado: (2011)

Structures of two aptamers with differing ligand specificity reveal ruggedness in the functional landscape of RNA
por: Knappenberger, Andrew John, et al.
Publicado: (2018)

Live-cell super-resolution microscopy reveals a primary role for diffusion in polyglutamine-driven aggresome assembly
por: Lu, Meng, et al.
Publicado: (2019)

Functional analyses of ancestral thioredoxins provide insights into their evolutionary history
por: Napolitano, Silvia, et al.
Publicado: (2019)

Rings of Charge within the Extracellular Vestibule Influence Ion Permeation of the 5-HT(3)A Receptor
por: Livesey, Matthew R., et al.
Publicado: (2011)

Structural and Functional Analysis of BipA, a Regulator of Virulence in Enteropathogenic Escherichia coli
por: Fan, Haitian, et al.
Publicado: (2015)

Direct Gating of ATP-activated Ion Channels (P2X2 Receptors) by Lipophilic Attachment at the Outer End of the Second Transmembrane Domain
por: Rothwell, Simon W., et al.
Publicado: (2014)

Investigations of the Contribution of a Putative Glycine Hinge to Ryanodine Receptor Channel Gating
por: Euden, Joanne, et al.
Publicado: (2013)

Cochlear impulse responses resolved into sets of gammatones: the case for beating of closely spaced local resonances
por: Bell, Andrew, et al.
Publicado: (2018)

Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels
por: Rubaiy, Hussein N., et al.
Publicado: (2017)

Evaluating the Capacity to Generate and Preserve Nitric Oxide Bioactivity in Highly Purified Earthworm Erythrocruorin: A GIANT POLYMERIC HEMOGLOBIN WITH POTENTIAL BLOOD SUBSTITUTE PROPERTIES
por: Roche, Camille J., et al.
Publicado: (2015)

Acceleration of α-Synuclein Aggregation by Exosomes
por: Grey, Marie, et al.
Publicado: (2015)

An Extended Active-site Motif Controls the Reactivity of the Thioredoxin Fold
por: Mavridou, Despoina A. I., et al.
Publicado: (2014)

Oligomerization of the Polycystin-2 C-terminal Tail and Effects on Its Ca(2+)-binding Properties
por: Yang, Yifei, et al.
Publicado: (2015)

Ligand-induced Epitope Masking: DISSOCIATION OF INTEGRIN α5β1-FIBRONECTIN COMPLEXES ONLY BY MONOCLONAL ANTIBODIES WITH AN ALLOSTERIC MODE OF ACTION
por: Mould, A. Paul, et al.
Publicado: (2016)

Inhibitory effects of cannabidiol on voltage-dependent sodium currents
por: Ghovanloo, Mohammad-Reza, et al.
Publicado: (2018)

Oxidation State-dependent Protein-Protein Interactions in Disulfide Cascades
por: Mavridou, Despoina A. I., et al.
Publicado: (2011)

Resting State Orai1 Diffuses as Homotetramer in the Plasma Membrane of Live Mammalian Cells
por: Madl, Josef, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_v8vkqeqj2cugklo7uvdgk5ruge