CYP2C9*3 polymorphism presenting as lethal subdural hematoma with low-dose warfarin

Warfarin is the most common and cheap oral anticoagulant currently used in clinical practice. A high inter-individual variation is seen in the response to warfarin. Recently, pharmacogenetics has gained importance in managing patients on warfarin, both in predicting the optimum required dose as well...

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Autores principales: Karnik, Niteen D., Sridharan, Kannan, Tiwari, D., Gupta, V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Drug Watch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175895/
https://www.ncbi.nlm.nih.gov/pubmed/25298588
http://dx.doi.org/10.4103/0253-7613.140594
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author Karnik, Niteen D.
Sridharan, Kannan
Tiwari, D.
Gupta, V.
author_facet Karnik, Niteen D.
Sridharan, Kannan
Tiwari, D.
Gupta, V.
author_sort Karnik, Niteen D.
collection PubMed
description Warfarin is the most common and cheap oral anticoagulant currently used in clinical practice. A high inter-individual variation is seen in the response to warfarin. Recently, pharmacogenetics has gained importance in managing patients on warfarin, both in predicting the optimum required dose as well as in decreasing the risk of bleeding. This case report is a description of a 49-year-old patient who had a lethal subdural hematoma with low-dose warfarin. He was subsequently found to have CYP2C9 gene polymorphism (*1/*3). This case report stresses the importance of pre-prescription assessment of genetic analysis for those initiated on warfarin.
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spelling pubmed-41758952014-10-08 CYP2C9*3 polymorphism presenting as lethal subdural hematoma with low-dose warfarin Karnik, Niteen D. Sridharan, Kannan Tiwari, D. Gupta, V. Indian J Pharmacol Drug Watch Warfarin is the most common and cheap oral anticoagulant currently used in clinical practice. A high inter-individual variation is seen in the response to warfarin. Recently, pharmacogenetics has gained importance in managing patients on warfarin, both in predicting the optimum required dose as well as in decreasing the risk of bleeding. This case report is a description of a 49-year-old patient who had a lethal subdural hematoma with low-dose warfarin. He was subsequently found to have CYP2C9 gene polymorphism (*1/*3). This case report stresses the importance of pre-prescription assessment of genetic analysis for those initiated on warfarin. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4175895/ /pubmed/25298588 http://dx.doi.org/10.4103/0253-7613.140594 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Drug Watch
Karnik, Niteen D.
Sridharan, Kannan
Tiwari, D.
Gupta, V.
CYP2C9*3 polymorphism presenting as lethal subdural hematoma with low-dose warfarin
title CYP2C9*3 polymorphism presenting as lethal subdural hematoma with low-dose warfarin
title_full CYP2C9*3 polymorphism presenting as lethal subdural hematoma with low-dose warfarin
title_fullStr CYP2C9*3 polymorphism presenting as lethal subdural hematoma with low-dose warfarin
title_full_unstemmed CYP2C9*3 polymorphism presenting as lethal subdural hematoma with low-dose warfarin
title_short CYP2C9*3 polymorphism presenting as lethal subdural hematoma with low-dose warfarin
title_sort cyp2c9*3 polymorphism presenting as lethal subdural hematoma with low-dose warfarin
topic Drug Watch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175895/
https://www.ncbi.nlm.nih.gov/pubmed/25298588
http://dx.doi.org/10.4103/0253-7613.140594
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