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Computational identification of RNA functional determinants by three-dimensional quantitative structure–activity relationships

Anti-infection drugs target vital functions of infectious agents, including their ribosome and other essential non-coding RNAs. One of the reasons infectious agents become resistant to drugs is due to mutations that eliminate drug-binding affinity while maintaining vital elements. Identifying these...

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Detalles Bibliográficos
Autores principales:	Blanchet, Marc-Frédérick, St-Onge, Karine, Lisi, Véronique, Robitaille, Julie, Hamel, Sylvie, Major, François
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176186/ https://www.ncbi.nlm.nih.gov/pubmed/25200082 http://dx.doi.org/10.1093/nar/gku816

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