Proteasome Activation is a Mechanism for Pyrazolone Small Molecules Displaying Therapeutic Potential in Amyotrophic Lateral Sclerosis

[Image: see text] Amyotrophic lateral sclerosis (ALS) is a progressive and ultimately fatal neurodegenerative disease. Pyrazolone containing small molecules have shown significant disease attenuating efficacy in cellular and murine models of ALS. Pyrazolone based affinity probes were synthesized to...

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Detalles Bibliográficos
Autores principales: Trippier, Paul C., Zhao, Kevin Tianmeng, Fox, Susan G., Schiefer, Isaac T., Benmohamed, Radhia, Moran, Jason, Kirsch, Donald R., Morimoto, Richard I., Silverman, Richard B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176317/
https://www.ncbi.nlm.nih.gov/pubmed/25001311
http://dx.doi.org/10.1021/cn500147v

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