Structural basis of lariat RNA recognition by the intron debranching enzyme Dbr1

The enzymatic processing of cellular RNA molecules requires selective recognition of unique chemical and topological features. The unusual 2′,5′-phosphodiester linkages in RNA lariats produced by the spliceosome must be hydrolyzed by the intron debranching enzyme (Dbr1) before they can be metabolize...

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Detalles Bibliográficos
Autores principales: Montemayor, Eric J., Katolik, Adam, Clark, Nathaniel E., Taylor, Alexander B., Schuermann, Jonathan P., Combs, D. Joshua, Johnsson, Richard, Holloway, Stephen P., Stevens, Scott W., Damha, Masad J., Hart, P. John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176325/
https://www.ncbi.nlm.nih.gov/pubmed/25123664
http://dx.doi.org/10.1093/nar/gku725

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