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Processing of double-R-loops in (CAG)·(CTG) and C9orf72 (GGGGCC)·(GGCCCC) repeats causes instability

R-loops, transcriptionally-induced RNA:DNA hybrids, occurring at repeat tracts (CTG)(n), (CAG)(n), (CGG)(n), (CCG)(n) and (GAA)(n), are associated with diseases including myotonic dystrophy, Huntington's disease, fragile X and Friedreich's ataxia. Many of these repeats are bidirectionally...

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Detalles Bibliográficos
Autores principales:	Reddy, Kaalak, Schmidt, Monika H.M., Geist, Jaimie M., Thakkar, Neha P., Panigrahi, Gagan B., Wang, Yuh-Hwa, Pearson, Christopher E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176329/ https://www.ncbi.nlm.nih.gov/pubmed/25147206 http://dx.doi.org/10.1093/nar/gku658

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