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Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding

Rad2/XPG belongs to the flap nuclease family and is responsible for a key step of the eukaryotic nucleotide excision DNA repair (NER) pathway. To elucidate the mechanism of DNA binding by Rad2/XPG, we solved crystal structures of the catalytic core of Rad2 in complex with a substrate. Rad2 utilizes...

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Detalles Bibliográficos
Autores principales:	Miętus, Michał, Nowak, Elżbieta, Jaciuk, Marcin, Kustosz, Paweł, Studnicka, Justyna, Nowotny, Marcin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176360/ https://www.ncbi.nlm.nih.gov/pubmed/25120270 http://dx.doi.org/10.1093/nar/gku729

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