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Semisynthetic Analogues of Toxiferine I and Their Pharmacological Properties at α7 nAChRs, Muscle-Type nAChRs, and the Allosteric Binding Site of Muscarinic M(2) Receptors
[Image: see text] A new series of analogues of the calabash curare alkaloid toxiferine I was prepared and pharmacologically evaluated at α7 and muscle-type nAChRs and the allosteric site of muscarinic M(2) receptors. The new ligands differ from toxiferine I by the absence of one (2a–c) or two (3a–c)...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society and American
Society of Pharmacognosy
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176391/ https://www.ncbi.nlm.nih.gov/pubmed/25192059 http://dx.doi.org/10.1021/np500259j |