Labeled Protein Recognition at a Membrane Bilayer Interface by Embedded Synthetic Receptors

[Image: see text] Self-folding deep cavitands embedded in a supported lipid bilayer are capable of recognizing suitably labeled proteins at the bilayer interface. The addition of a choline derived binding “handle” to a number of different proteins allows their selective noncovalent recognition, with...

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Autores principales: Ghang, Yoo-Jin, Lloyd, Jonathan J., Moehlig, Melissa P., Arguelles, Jessica K., Mettry, Magi, Zhang, Xing, Julian, Ryan R., Cheng, Quan, Hooley, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176395/
https://www.ncbi.nlm.nih.gov/pubmed/25130415
http://dx.doi.org/10.1021/la502629d
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author Ghang, Yoo-Jin
Lloyd, Jonathan J.
Moehlig, Melissa P.
Arguelles, Jessica K.
Mettry, Magi
Zhang, Xing
Julian, Ryan R.
Cheng, Quan
Hooley, Richard J.
author_facet Ghang, Yoo-Jin
Lloyd, Jonathan J.
Moehlig, Melissa P.
Arguelles, Jessica K.
Mettry, Magi
Zhang, Xing
Julian, Ryan R.
Cheng, Quan
Hooley, Richard J.
author_sort Ghang, Yoo-Jin
collection PubMed
description [Image: see text] Self-folding deep cavitands embedded in a supported lipid bilayer are capable of recognizing suitably labeled proteins at the bilayer interface. The addition of a choline derived binding “handle” to a number of different proteins allows their selective noncovalent recognition, with association constants on the order of 10(5) M(–1). The proteins are displayed at the water:bilayer interface, and a single binding handle allows recognition of the large, charged protein by a small molecule synthetic receptor via complementary shape and charge interactions.
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spelling pubmed-41763952015-08-17 Labeled Protein Recognition at a Membrane Bilayer Interface by Embedded Synthetic Receptors Ghang, Yoo-Jin Lloyd, Jonathan J. Moehlig, Melissa P. Arguelles, Jessica K. Mettry, Magi Zhang, Xing Julian, Ryan R. Cheng, Quan Hooley, Richard J. Langmuir [Image: see text] Self-folding deep cavitands embedded in a supported lipid bilayer are capable of recognizing suitably labeled proteins at the bilayer interface. The addition of a choline derived binding “handle” to a number of different proteins allows their selective noncovalent recognition, with association constants on the order of 10(5) M(–1). The proteins are displayed at the water:bilayer interface, and a single binding handle allows recognition of the large, charged protein by a small molecule synthetic receptor via complementary shape and charge interactions. American Chemical Society 2014-08-17 2014-09-02 /pmc/articles/PMC4176395/ /pubmed/25130415 http://dx.doi.org/10.1021/la502629d Text en Copyright © 2014 American Chemical Society Terms of Use (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html)
spellingShingle Ghang, Yoo-Jin
Lloyd, Jonathan J.
Moehlig, Melissa P.
Arguelles, Jessica K.
Mettry, Magi
Zhang, Xing
Julian, Ryan R.
Cheng, Quan
Hooley, Richard J.
Labeled Protein Recognition at a Membrane Bilayer Interface by Embedded Synthetic Receptors
title Labeled Protein Recognition at a Membrane Bilayer Interface by Embedded Synthetic Receptors
title_full Labeled Protein Recognition at a Membrane Bilayer Interface by Embedded Synthetic Receptors
title_fullStr Labeled Protein Recognition at a Membrane Bilayer Interface by Embedded Synthetic Receptors
title_full_unstemmed Labeled Protein Recognition at a Membrane Bilayer Interface by Embedded Synthetic Receptors
title_short Labeled Protein Recognition at a Membrane Bilayer Interface by Embedded Synthetic Receptors
title_sort labeled protein recognition at a membrane bilayer interface by embedded synthetic receptors
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176395/
https://www.ncbi.nlm.nih.gov/pubmed/25130415
http://dx.doi.org/10.1021/la502629d
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