Notolutesins A–J, Dolabrane-Type Diterpenoids from the Chinese Liverwort Notoscyphus lutescens

[Image: see text] Ten new dolabrane-type diterpenoids, notolutesins A–J (1–10), were isolated from the Chinese liverwort Notoscyphus lutescens, along with four known compounds. The structures of the new compounds were established on the basis of extensive spectroscopic data, and that of 1 was confir...

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Detalles Bibliográficos
Autores principales: Wang, Song, Li, Rui-Juan, Zhu, Rong-Xiu, Hu, Xiao-Yan, Guo, Yan-Xia, Zhou, Jin-Chuan, Lin, Zhao-Min, Zhang, Jiao-Zhen, Wu, Jing-Yi, Kang, Ya-Qi, Morris-Natschke, Susan L., Lee, Kuo-Hsiung, Yuan, Hui-Qing, Lou, Hong-Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society and American Society of Pharmacognosy 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176396/
https://www.ncbi.nlm.nih.gov/pubmed/25226363
http://dx.doi.org/10.1021/np5004559
Descripción
Sumario:[Image: see text] Ten new dolabrane-type diterpenoids, notolutesins A–J (1–10), were isolated from the Chinese liverwort Notoscyphus lutescens, along with four known compounds. The structures of the new compounds were established on the basis of extensive spectroscopic data, and that of 1 was confirmed by single-crystal X-ray crystallography. The absolute configuration of 1 was determined by comparing its experimental and calculated electronic circular dichroism spectra. All of the isolates were evaluated for their cytotoxicity against a small panel of human cancer cell lines, and compound 1 exhibited an IC(50) value of 6.2 μM against the PC3 human prostate cancer cell line.

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