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A Novel I221L Substitution in Neuraminidase Confers High-Level Resistance to Oseltamivir in Influenza B Viruses

Influenza B viruses with a novel I221L substitution in neuraminidase (NA) conferring high-level resistance to oseltamivir were isolated from an immunocompromised patient after prolonged oseltamivir treatment. Methods. Enzymatic characterization of the NAs (Km, Ki) and the in vitro fitness of viruses...

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Detalles Bibliográficos
Autores principales:	Escuret, Vanessa, Collins, Patrick J., Casalegno, Jean-Sébastien, Vachieri, Sebastien G., Cattle, Nicholas, Ferraris, Olivier, Sabatier, Murielle, Frobert, Emilie, Caro, Valérie, Skehel, John J., Gamblin, Steve, Valla, Frédéric, Valette, Martine, Ottmann, Michèle, McCauley, John W., Daniels, Rodney S., Lina, Bruno
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Major Articles and Brief Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176448/ https://www.ncbi.nlm.nih.gov/pubmed/24795482 http://dx.doi.org/10.1093/infdis/jiu244

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