The G-Protein-Coupled Long-Chain Fatty Acid Receptor GPR40 and Glucose Metabolism

Free fatty acids (FFAs) play a pivotal role in metabolic control and cell signaling processes in various tissues. In particular, FFAs are known to augment glucose-stimulated insulin secretion by pancreatic beta cells, where fatty acid-derived metabolites, such as long-chain fatty acyl-CoAs, are beli...

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Autores principales: Tomita, Tsutomu, Hosoda, Kiminori, Fujikura, Junji, Inagaki, Nobuya, Nakao, Kazuwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176464/
https://www.ncbi.nlm.nih.gov/pubmed/25309513
http://dx.doi.org/10.3389/fendo.2014.00152
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author Tomita, Tsutomu
Hosoda, Kiminori
Fujikura, Junji
Inagaki, Nobuya
Nakao, Kazuwa
author_facet Tomita, Tsutomu
Hosoda, Kiminori
Fujikura, Junji
Inagaki, Nobuya
Nakao, Kazuwa
author_sort Tomita, Tsutomu
collection PubMed
description Free fatty acids (FFAs) play a pivotal role in metabolic control and cell signaling processes in various tissues. In particular, FFAs are known to augment glucose-stimulated insulin secretion by pancreatic beta cells, where fatty acid-derived metabolites, such as long-chain fatty acyl-CoAs, are believed to act as crucial effectors. Recently, G-protein-coupled receptor 40 (GPR40), a receptor for long-chain fatty acids, was reported to be highly expressed in pancreatic beta cells and involved in the regulation of insulin secretion. Hence, GPR40 is considered to be a potential therapeutic target for the treatment of diabetes. In this review, we summarize the identification and gene expression patterns of GPR40 and its role in glucose metabolism. We also discuss the potential application of GPR40 as a therapeutic target.
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spelling pubmed-41764642014-10-10 The G-Protein-Coupled Long-Chain Fatty Acid Receptor GPR40 and Glucose Metabolism Tomita, Tsutomu Hosoda, Kiminori Fujikura, Junji Inagaki, Nobuya Nakao, Kazuwa Front Endocrinol (Lausanne) Endocrinology Free fatty acids (FFAs) play a pivotal role in metabolic control and cell signaling processes in various tissues. In particular, FFAs are known to augment glucose-stimulated insulin secretion by pancreatic beta cells, where fatty acid-derived metabolites, such as long-chain fatty acyl-CoAs, are believed to act as crucial effectors. Recently, G-protein-coupled receptor 40 (GPR40), a receptor for long-chain fatty acids, was reported to be highly expressed in pancreatic beta cells and involved in the regulation of insulin secretion. Hence, GPR40 is considered to be a potential therapeutic target for the treatment of diabetes. In this review, we summarize the identification and gene expression patterns of GPR40 and its role in glucose metabolism. We also discuss the potential application of GPR40 as a therapeutic target. Frontiers Media S.A. 2014-09-26 /pmc/articles/PMC4176464/ /pubmed/25309513 http://dx.doi.org/10.3389/fendo.2014.00152 Text en Copyright © 2014 Tomita, Hosoda, Fujikura, Inagaki and Nakao. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Tomita, Tsutomu
Hosoda, Kiminori
Fujikura, Junji
Inagaki, Nobuya
Nakao, Kazuwa
The G-Protein-Coupled Long-Chain Fatty Acid Receptor GPR40 and Glucose Metabolism
title The G-Protein-Coupled Long-Chain Fatty Acid Receptor GPR40 and Glucose Metabolism
title_full The G-Protein-Coupled Long-Chain Fatty Acid Receptor GPR40 and Glucose Metabolism
title_fullStr The G-Protein-Coupled Long-Chain Fatty Acid Receptor GPR40 and Glucose Metabolism
title_full_unstemmed The G-Protein-Coupled Long-Chain Fatty Acid Receptor GPR40 and Glucose Metabolism
title_short The G-Protein-Coupled Long-Chain Fatty Acid Receptor GPR40 and Glucose Metabolism
title_sort g-protein-coupled long-chain fatty acid receptor gpr40 and glucose metabolism
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176464/
https://www.ncbi.nlm.nih.gov/pubmed/25309513
http://dx.doi.org/10.3389/fendo.2014.00152
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