Comparative study of four immortalized human brain capillary endothelial cell lines, hCMEC/D3, hBMEC, TY10, and BB19, and optimization of culture conditions, for an in vitro blood–brain barrier model for drug permeability studies

BACKGROUND: Reliable human in vitro blood–brain barrier (BBB) models suitable for high-throughput screening are urgently needed in early drug discovery and development for assessing the ability of promising bioactive compounds to overcome the BBB. To establish an improved human in vitro BBB model, w...

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Detalles Bibliográficos
Autores principales: Eigenmann, Daniela E, Xue, Gongda, Kim, Kwang S, Moses, Ashlee V, Hamburger, Matthias, Oufir, Mouhssin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176484/
https://www.ncbi.nlm.nih.gov/pubmed/24262108
http://dx.doi.org/10.1186/2045-8118-10-33

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