Enhanced Fitness of Adult Spermatogonial Stem Cells Bearing a Paternal Age-Associated FGFR2 Mutation

Pathogenic de novo mutations increase with fathers’ age and could be amplified through competition between genetically distinct subpopulations of spermatogonial stem cells (SSCs). Here, we tested the fitness of SSCs bearing wild-type human FGFR2 or an Apert syndrome mutant, FGFR2 (S252W), to provide...

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Detalles Bibliográficos
Autores principales: Martin, Laura A., Assif, Nicholas, Gilbert, Moses, Wijewarnasuriya, Dinali, Seandel, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176532/
https://www.ncbi.nlm.nih.gov/pubmed/25254335
http://dx.doi.org/10.1016/j.stemcr.2014.06.007

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