Cargando…

Structural Basis of Binding and Rationale for the Potent Urease Inhibitory Activity of Biscoumarins

Urease belongs to a family of highly conserved urea-hydrolyzing enzymes. A common feature of these enzymes is the presence of two Lewis acid nickel ions and reactive cysteine residue in the active sites. In the current study we examined a series of biscoumarins 1–10 for their mechanisms of inhibitio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lodhi, Muhammad Arif, Shams, Sulaiman, Choudhary, Muhammad Iqbal, Lodhi, Atif, Ul-Haq, Zaheer, Jalil, Saima, Nawaz, Sarfraz Ahmad, Khan, Khalid Mohammed, Iqbal, Sajid, Rahman, Atta-ur
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176650/ https://www.ncbi.nlm.nih.gov/pubmed/25295281 http://dx.doi.org/10.1155/2014/935039

Ejemplares similares

Design of New and Potent Diethyl Thiobarbiturates as Urease Inhibitors: A Computational Approach
por: Wadood, Abdul, et al.
Publicado: (2014)

Synthesis and dynamics studies of barbituric acid derivatives as urease inhibitors
por: Barakat, Assem, et al.
Publicado: (2015)

2-Mercaptobenzimidazole clubbed hydrazone for Alzheimer’s therapy: In vitro, kinetic, in silico, and in vivo potentials
por: Begum, Farida, et al.
Publicado: (2022)

Crystal engineering of exemestane to obtain a co-crystal with enhanced urease inhibition activity
por: Fatima, Syeda Saima, et al.
Publicado: (2020)

Antibacterial and Antitumor Activities of Biscoumarin and Dihydropyran Derivatives
por: Sui, Yun-Peng, et al.
Publicado: (2015)

Synthesis of Biscoumarin and Dihydropyran Derivatives and Evaluation of Their Antibacterial Activity
por: Li, Jing, et al.
Publicado: (2015)

Bioinformatics: A rational combine approach used for the identification and in-vitro activity evaluation of potent β-Glucuronidase inhibitors
por: Yousuf, Maria, et al.
Publicado: (2018)

Molecular docking simulation studies on potent butyrylcholinesterase inhibitors obtained from microbial transformation of dihydrotestosterone
por: Zafar, Salman, et al.
Publicado: (2013)

Designing Potent α-Glucosidase Inhibitors: A Synthesis and QSAR Modeling Approach for Biscoumarin Derivatives
por: Phan, Thi-Hong-Truc, et al.
Publicado: (2023)

Ruthenium(II)(η(6)-arene) Complexes of Thiourea Derivatives: Synthesis, Characterization and Urease Inhibition
por: Hanif, Muhammad, et al.
Publicado: (2014)

3D-QSAR Studies on Barbituric Acid Derivatives as Urease Inhibitors and the Effect of Charges on the Quality of a Model
por: Ul-Haq, Zaheer, et al.
Publicado: (2016)

N-Aryl-3,4-dihydroisoquinoline Carbothioamide Analogues as Potential Urease Inhibitors
por: Ali, Fayaz, et al.
Publicado: (2021)

Soil urease inhibition by various plant extracts
por: Rana, Muhammad Ajmal, et al.
Publicado: (2021)

Phytohormones Producing Acinetobacter bouvetii P1 Mitigates Chromate Stress in Sunflower by Provoking Host Antioxidant Response
por: Qadir, Muhammad, et al.
Publicado: (2021)

Robust Synthesis of Ciprofloxacin-Capped Metallic Nanoparticles and Their Urease Inhibitory Assay
por: Nisar, Muhammad, et al.
Publicado: (2016)

A Rare Case of Paroxysmal Nocturnal Hemoglobinuria With Bilateral Renal Vein Thrombosis
por: Lodhi, Omair ul haq, et al.
Publicado: (2020)

A Rare Case of Acute Transverse Myelitis (ATM) and Acute Motor and Sensory Axonal Neuropathy (AMSAN) Overlap
por: Javed, Zarmina, et al.
Publicado: (2019)

A multi-target therapeutic potential of Prunus domestica gum stabilized nanoparticles exhibited prospective anticancer, antibacterial, urease-inhibition, anti-inflammatory and analgesic properties.
por: Islam, Nazar Ul, et al.
Publicado: (2017)

New solid phase methodology for the synthesis of biscoumarin derivatives: experimental and in silico approaches
por: Zarenezhad, Elham, et al.
Publicado: (2022)

Comparison of High-Resolution Computed Tomography and Real-Time Reverse Transcriptase Polymerase Chain Reaction in Diagnosis of COVID-19 Pneumonia in Intensive Care Unit Population
por: Murtaza, Hafiz G, et al.
Publicado: (2021)

Biodiesel production from microalgal isolates of southern Pakistan and quantification of FAMEs by GC-MS/MS analysis
por: Musharraf, Syed Ghulam, et al.
Publicado: (2012)

Ultrasound-Assisted Metal-Mediated Method for the Formation of Tetrahydro-3,3′-Disubstituted Biscoumarins
por: Koleva, Ana I., et al.
Publicado: (2018)

Synthesis, Urease Inhibition, Antioxidant, Antibacterial, and Molecular Docking Studies of 1,3,4-Oxadiazole Derivatives
por: Hanif, Muhammad, et al.
Publicado: (2012)

Benzimidazole, coumrindione and flavone derivatives as alternate UV laser desorption ionization (LDI) matrices for peptides analysis
por: Musharraf, Syed Ghulam, et al.
Publicado: (2013)

A Unique Case of Acute Cerebral Venous Sinus Thrombosis Secondary to Primary Varicella Zoster Virus Infection
por: Imam, Syed F, et al.
Publicado: (2017)

Synthesis, Density Functional Theory (DFT), Urease Inhibition and Antimicrobial Activities of 5-Aryl Thiophenes Bearing Sulphonylacetamide Moieties
por: Noreen, Mnaza, et al.
Publicado: (2015)

In Silico Study of Alkaloids as α-Glucosidase Inhibitors: Hope for the Discovery of Effective Lead Compounds
por: Zafar, Muhammad, et al.
Publicado: (2016)

A Rare Coincidence of Measles with Typhoid Fever
por: Lodhi, Omair ul haq, et al.
Publicado: (2017)

Crystal structure of 4-[(E)-(2-carbamothioylhydrazinylidene)methyl]benzoic acid
por: Tahir, Muhammad Nawaz, et al.
Publicado: (2015)

Polarized, V-Shaped, and Conjoined Biscoumarins: From Lack of Dipole Moment Alignment to High Brightness
por: Kielesiński, Łukasz, et al.
Publicado: (2022)

Ionic-Liquid-Stabilized TiO(2) Nanostructures: A Platform for Detection of Hydrogen Peroxide
por: Nishan, Umar, et al.
Publicado: (2021)

Studies on Isoniazid Derivatives through a Medicinal Chemistry Approach for the Identification of New Inhibitors of Urease and Inflammatory Markers
por: Rizvi, Fazila, et al.
Publicado: (2019)

Molecular docking study of P4-Benzoxaborolesubstituted ligands as inhibitors of HCV NS3/4A protease
por: Wadood, Abdul, et al.
Publicado: (2013)

Enzyme Inhibitory Kinetics and Molecular Docking Studies of Halo-Substituted Mixed Ester/Amide-Based Derivatives as Jack Bean Urease Inhibitors
por: Rashid, Muhammad, et al.
Publicado: (2020)

In-vitro immunomodulatory and anti-cancerous activities of biotransformed products of Dianabol through Azadirachta indica and its molecular docking studies
por: Saifullah, et al.
Publicado: (2013)

Plasma Metabolite Profiling and Chemometric Analyses of Lung Cancer along with Three Controls through Gas Chromatography-Mass Spectrometry
por: Musharraf, Syed Ghulam, et al.
Publicado: (2015)

Probing the chemical constituents of Cassia javanica and its in vitro analyses as a potent drug
por: Haleem, Muhammad Abdul, et al.
Publicado: (2022)

Dynamic changes in the secondary structure of ECE-1 and XCE account for their different substrate specificities
por: Ul-Haq, Zaheer, et al.
Publicado: (2012)

New Biscoumarin Derivatives: Synthesis, Crystal Structure, Theoretical Study and Antibacterial Activity against Staphylococcus aureus
por: Qu, Di, et al.
Publicado: (2014)

Inhibitory Effects of Myrtucommuacetalone 1 (MCA-1) from Myrtus Communis on Inflammatory Response in Mouse Macrophages
por: Soomro, Samreen, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_eiut2b8lu0a181gbn773fbud6j