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Polymersome magneto-valves for reversible capture and release of nanoparticles

Stomatocytes are polymersomes with an infolded bowl-shaped architecture. This internal cavity is connected to the outside environment via a small ‘mouth’ region. Stomatocytes are assembled from diamagnetic amphiphilic block-copolymers with a highly anisotropic magnetic susceptibility, which permits...

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Autores principales: van Rhee, P.G., Rikken, R.S.M., Abdelmohsen, L.K.E.A., Maan, J.C., Nolte, R.J.M., van Hest, J.C.M., Christianen, P.C.M., Wilson, D.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176683/
https://www.ncbi.nlm.nih.gov/pubmed/25248402
http://dx.doi.org/10.1038/ncomms6010
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author van Rhee, P.G.
Rikken, R.S.M.
Abdelmohsen, L.K.E.A.
Maan, J.C.
Nolte, R.J.M.
van Hest, J.C.M.
Christianen, P.C.M.
Wilson, D.A.
author_facet van Rhee, P.G.
Rikken, R.S.M.
Abdelmohsen, L.K.E.A.
Maan, J.C.
Nolte, R.J.M.
van Hest, J.C.M.
Christianen, P.C.M.
Wilson, D.A.
author_sort van Rhee, P.G.
collection PubMed
description Stomatocytes are polymersomes with an infolded bowl-shaped architecture. This internal cavity is connected to the outside environment via a small ‘mouth’ region. Stomatocytes are assembled from diamagnetic amphiphilic block-copolymers with a highly anisotropic magnetic susceptibility, which permits to magnetically align and deform the polymeric self-assemblies. Here we show the reversible opening and closing of the mouth region of stomatocytes in homogeneous magnetic fields. The control over the size of the opening yields magneto-responsive supramolecular valves that are able to reversibly capture and release cargo. Furthermore, the increase in the size of the opening is gradual and starts at fields below 10 T, which opens the possibility of using these structures for delivery and nanoreactor applications.
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spelling pubmed-41766832014-10-21 Polymersome magneto-valves for reversible capture and release of nanoparticles van Rhee, P.G. Rikken, R.S.M. Abdelmohsen, L.K.E.A. Maan, J.C. Nolte, R.J.M. van Hest, J.C.M. Christianen, P.C.M. Wilson, D.A. Nat Commun Article Stomatocytes are polymersomes with an infolded bowl-shaped architecture. This internal cavity is connected to the outside environment via a small ‘mouth’ region. Stomatocytes are assembled from diamagnetic amphiphilic block-copolymers with a highly anisotropic magnetic susceptibility, which permits to magnetically align and deform the polymeric self-assemblies. Here we show the reversible opening and closing of the mouth region of stomatocytes in homogeneous magnetic fields. The control over the size of the opening yields magneto-responsive supramolecular valves that are able to reversibly capture and release cargo. Furthermore, the increase in the size of the opening is gradual and starts at fields below 10 T, which opens the possibility of using these structures for delivery and nanoreactor applications. Nature Pub. Group 2014-09-24 /pmc/articles/PMC4176683/ /pubmed/25248402 http://dx.doi.org/10.1038/ncomms6010 Text en Copyright © 2014, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
van Rhee, P.G.
Rikken, R.S.M.
Abdelmohsen, L.K.E.A.
Maan, J.C.
Nolte, R.J.M.
van Hest, J.C.M.
Christianen, P.C.M.
Wilson, D.A.
Polymersome magneto-valves for reversible capture and release of nanoparticles
title Polymersome magneto-valves for reversible capture and release of nanoparticles
title_full Polymersome magneto-valves for reversible capture and release of nanoparticles
title_fullStr Polymersome magneto-valves for reversible capture and release of nanoparticles
title_full_unstemmed Polymersome magneto-valves for reversible capture and release of nanoparticles
title_short Polymersome magneto-valves for reversible capture and release of nanoparticles
title_sort polymersome magneto-valves for reversible capture and release of nanoparticles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176683/
https://www.ncbi.nlm.nih.gov/pubmed/25248402
http://dx.doi.org/10.1038/ncomms6010
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