8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia

The pathogenetic roles of 8q24 amplified segments in leukemic cells with double minute chromosomes remain to be verified. Through comprehensive molecular analyses of 8q24 amplicons in leukemic cells from an acute myelogenous leukemia (AML) patient and AML-derived cell line HL60 cells, we identified...

Descripción completa

Detalles Bibliográficos
Autores principales: Chinen, Yoshiaki, Sakamoto, Natsumi, Nagoshi, Hisao, Taki, Tomohiko, Maegawa, Saori, Tatekawa, Shotaro, Tsukamoto, Taku, Mizutani, Shinsuke, Shimura, Yuji, Yamamoto-Sugitani, Mio, Kobayashi, Tsutomu, Matsumoto, Yosuke, Horiike, Shigeo, Kuroda, Junya, Taniwaki, Masafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176872/
https://www.ncbi.nlm.nih.gov/pubmed/25245984
http://dx.doi.org/10.1186/s13045-014-0068-2
_version_ 1782336687012052992
author Chinen, Yoshiaki
Sakamoto, Natsumi
Nagoshi, Hisao
Taki, Tomohiko
Maegawa, Saori
Tatekawa, Shotaro
Tsukamoto, Taku
Mizutani, Shinsuke
Shimura, Yuji
Yamamoto-Sugitani, Mio
Kobayashi, Tsutomu
Matsumoto, Yosuke
Horiike, Shigeo
Kuroda, Junya
Taniwaki, Masafumi
author_facet Chinen, Yoshiaki
Sakamoto, Natsumi
Nagoshi, Hisao
Taki, Tomohiko
Maegawa, Saori
Tatekawa, Shotaro
Tsukamoto, Taku
Mizutani, Shinsuke
Shimura, Yuji
Yamamoto-Sugitani, Mio
Kobayashi, Tsutomu
Matsumoto, Yosuke
Horiike, Shigeo
Kuroda, Junya
Taniwaki, Masafumi
author_sort Chinen, Yoshiaki
collection PubMed
description The pathogenetic roles of 8q24 amplified segments in leukemic cells with double minute chromosomes remain to be verified. Through comprehensive molecular analyses of 8q24 amplicons in leukemic cells from an acute myelogenous leukemia (AML) patient and AML-derived cell line HL60 cells, we identified two novel fusion genes between NSMCE2 and long noncoding RNAs (lncRNAs), namely, PVT1-NSMCE2 and BF104016-NSMCE2. Our study suggests that 8q24 amplicons are associated with the emergence of aberrant chimeric genes between NSMCE2 and oncogenic lncRNAs, and also implicate that the chimeric genes involving lncRNAs potentially possess as-yet-unknown oncogenic functional roles. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13045-014-0068-2) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-4176872
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-41768722014-09-28 8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia Chinen, Yoshiaki Sakamoto, Natsumi Nagoshi, Hisao Taki, Tomohiko Maegawa, Saori Tatekawa, Shotaro Tsukamoto, Taku Mizutani, Shinsuke Shimura, Yuji Yamamoto-Sugitani, Mio Kobayashi, Tsutomu Matsumoto, Yosuke Horiike, Shigeo Kuroda, Junya Taniwaki, Masafumi J Hematol Oncol Letter to the Editor The pathogenetic roles of 8q24 amplified segments in leukemic cells with double minute chromosomes remain to be verified. Through comprehensive molecular analyses of 8q24 amplicons in leukemic cells from an acute myelogenous leukemia (AML) patient and AML-derived cell line HL60 cells, we identified two novel fusion genes between NSMCE2 and long noncoding RNAs (lncRNAs), namely, PVT1-NSMCE2 and BF104016-NSMCE2. Our study suggests that 8q24 amplicons are associated with the emergence of aberrant chimeric genes between NSMCE2 and oncogenic lncRNAs, and also implicate that the chimeric genes involving lncRNAs potentially possess as-yet-unknown oncogenic functional roles. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13045-014-0068-2) contains supplementary material, which is available to authorized users. BioMed Central 2014-09-23 /pmc/articles/PMC4176872/ /pubmed/25245984 http://dx.doi.org/10.1186/s13045-014-0068-2 Text en © Chinen et al.; licensee BioMed Central Ltd. 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter to the Editor
Chinen, Yoshiaki
Sakamoto, Natsumi
Nagoshi, Hisao
Taki, Tomohiko
Maegawa, Saori
Tatekawa, Shotaro
Tsukamoto, Taku
Mizutani, Shinsuke
Shimura, Yuji
Yamamoto-Sugitani, Mio
Kobayashi, Tsutomu
Matsumoto, Yosuke
Horiike, Shigeo
Kuroda, Junya
Taniwaki, Masafumi
8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia
title 8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia
title_full 8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia
title_fullStr 8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia
title_full_unstemmed 8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia
title_short 8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia
title_sort 8q24 amplified segments involve novel fusion genes between nsmce2 and long noncoding rnas in acute myelogenous leukemia
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176872/
https://www.ncbi.nlm.nih.gov/pubmed/25245984
http://dx.doi.org/10.1186/s13045-014-0068-2
work_keys_str_mv AT chinenyoshiaki 8q24amplifiedsegmentsinvolvenovelfusiongenesbetweennsmce2andlongnoncodingrnasinacutemyelogenousleukemia
AT sakamotonatsumi 8q24amplifiedsegmentsinvolvenovelfusiongenesbetweennsmce2andlongnoncodingrnasinacutemyelogenousleukemia
AT nagoshihisao 8q24amplifiedsegmentsinvolvenovelfusiongenesbetweennsmce2andlongnoncodingrnasinacutemyelogenousleukemia
AT takitomohiko 8q24amplifiedsegmentsinvolvenovelfusiongenesbetweennsmce2andlongnoncodingrnasinacutemyelogenousleukemia
AT maegawasaori 8q24amplifiedsegmentsinvolvenovelfusiongenesbetweennsmce2andlongnoncodingrnasinacutemyelogenousleukemia
AT tatekawashotaro 8q24amplifiedsegmentsinvolvenovelfusiongenesbetweennsmce2andlongnoncodingrnasinacutemyelogenousleukemia
AT tsukamototaku 8q24amplifiedsegmentsinvolvenovelfusiongenesbetweennsmce2andlongnoncodingrnasinacutemyelogenousleukemia
AT mizutanishinsuke 8q24amplifiedsegmentsinvolvenovelfusiongenesbetweennsmce2andlongnoncodingrnasinacutemyelogenousleukemia
AT shimurayuji 8q24amplifiedsegmentsinvolvenovelfusiongenesbetweennsmce2andlongnoncodingrnasinacutemyelogenousleukemia
AT yamamotosugitanimio 8q24amplifiedsegmentsinvolvenovelfusiongenesbetweennsmce2andlongnoncodingrnasinacutemyelogenousleukemia
AT kobayashitsutomu 8q24amplifiedsegmentsinvolvenovelfusiongenesbetweennsmce2andlongnoncodingrnasinacutemyelogenousleukemia
AT matsumotoyosuke 8q24amplifiedsegmentsinvolvenovelfusiongenesbetweennsmce2andlongnoncodingrnasinacutemyelogenousleukemia
AT horiikeshigeo 8q24amplifiedsegmentsinvolvenovelfusiongenesbetweennsmce2andlongnoncodingrnasinacutemyelogenousleukemia
AT kurodajunya 8q24amplifiedsegmentsinvolvenovelfusiongenesbetweennsmce2andlongnoncodingrnasinacutemyelogenousleukemia
AT taniwakimasafumi 8q24amplifiedsegmentsinvolvenovelfusiongenesbetweennsmce2andlongnoncodingrnasinacutemyelogenousleukemia

Ejemplares similares