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Accelerated Corneal Collagen Cross-Linking in Pediatric Patients: Two-Year Follow-Up Results

Purpose. To evaluate the effectiveness and safety of accelerated corneal collagen cross-linking (ACXL) in patients below 14 years of age with progressive keratoconus. Materials and Methods. Thirty eyes of 18 patients with established progressive keratoconus underwent preoperative and postoperative v...

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Autores principales: Shetty, Rohit, Nagaraja, Harsha, Jayadev, Chaitra, Pahuja, Natasha Kishore, Kurian Kummelil, Mathew, Nuijts, Rudy M. M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176916/
https://www.ncbi.nlm.nih.gov/pubmed/25295278
http://dx.doi.org/10.1155/2014/894095
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author Shetty, Rohit
Nagaraja, Harsha
Jayadev, Chaitra
Pahuja, Natasha Kishore
Kurian Kummelil, Mathew
Nuijts, Rudy M. M. A.
author_facet Shetty, Rohit
Nagaraja, Harsha
Jayadev, Chaitra
Pahuja, Natasha Kishore
Kurian Kummelil, Mathew
Nuijts, Rudy M. M. A.
author_sort Shetty, Rohit
collection PubMed
description Purpose. To evaluate the effectiveness and safety of accelerated corneal collagen cross-linking (ACXL) in patients below 14 years of age with progressive keratoconus. Materials and Methods. Thirty eyes of 18 patients with established progressive keratoconus underwent preoperative and postoperative visual acuity assessment, topography, and specular microscopy prior to ACXL and were followed up for 24 months. Results. Mean age of the patients was 12.7 years with ten males and eight females. There was an improvement in the mean postoperative uncorrected distant visual acuity (from 0.76 ± 0.26 to 0.61 ± 0.25; P = 0.005), mean corrected distant visual acuity (from 0.24 ± 0.19 to 0.12 ± 0.12; P < 0.001), mean spherical refraction (from −3.04 DS ± 3.60 to −2.38 DS ± 3.37; P = 0.28), mean cylinder (from −3.63 DC ± 1.82 to −2.80 DC ± 1.48; P = 0.008), and spherical equivalent (from −4.70 D ± 3.86 to −3.75 D ± 3.49; P = 0.15). Three eyes of two patients with vernal keratoconjunctivitis (VKC) showed progression. There were no intra- or postoperative complications. Conclusion. In pediatric patients ACXL is an effective and safe procedure for the management of keratoconus. Optimal management of VKC is important to arrest the progression of keratoconus.
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spelling pubmed-41769162014-10-07 Accelerated Corneal Collagen Cross-Linking in Pediatric Patients: Two-Year Follow-Up Results Shetty, Rohit Nagaraja, Harsha Jayadev, Chaitra Pahuja, Natasha Kishore Kurian Kummelil, Mathew Nuijts, Rudy M. M. A. Biomed Res Int Clinical Study Purpose. To evaluate the effectiveness and safety of accelerated corneal collagen cross-linking (ACXL) in patients below 14 years of age with progressive keratoconus. Materials and Methods. Thirty eyes of 18 patients with established progressive keratoconus underwent preoperative and postoperative visual acuity assessment, topography, and specular microscopy prior to ACXL and were followed up for 24 months. Results. Mean age of the patients was 12.7 years with ten males and eight females. There was an improvement in the mean postoperative uncorrected distant visual acuity (from 0.76 ± 0.26 to 0.61 ± 0.25; P = 0.005), mean corrected distant visual acuity (from 0.24 ± 0.19 to 0.12 ± 0.12; P < 0.001), mean spherical refraction (from −3.04 DS ± 3.60 to −2.38 DS ± 3.37; P = 0.28), mean cylinder (from −3.63 DC ± 1.82 to −2.80 DC ± 1.48; P = 0.008), and spherical equivalent (from −4.70 D ± 3.86 to −3.75 D ± 3.49; P = 0.15). Three eyes of two patients with vernal keratoconjunctivitis (VKC) showed progression. There were no intra- or postoperative complications. Conclusion. In pediatric patients ACXL is an effective and safe procedure for the management of keratoconus. Optimal management of VKC is important to arrest the progression of keratoconus. Hindawi Publishing Corporation 2014 2014-09-11 /pmc/articles/PMC4176916/ /pubmed/25295278 http://dx.doi.org/10.1155/2014/894095 Text en Copyright © 2014 Rohit Shetty et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Shetty, Rohit
Nagaraja, Harsha
Jayadev, Chaitra
Pahuja, Natasha Kishore
Kurian Kummelil, Mathew
Nuijts, Rudy M. M. A.
Accelerated Corneal Collagen Cross-Linking in Pediatric Patients: Two-Year Follow-Up Results
title Accelerated Corneal Collagen Cross-Linking in Pediatric Patients: Two-Year Follow-Up Results
title_full Accelerated Corneal Collagen Cross-Linking in Pediatric Patients: Two-Year Follow-Up Results
title_fullStr Accelerated Corneal Collagen Cross-Linking in Pediatric Patients: Two-Year Follow-Up Results
title_full_unstemmed Accelerated Corneal Collagen Cross-Linking in Pediatric Patients: Two-Year Follow-Up Results
title_short Accelerated Corneal Collagen Cross-Linking in Pediatric Patients: Two-Year Follow-Up Results
title_sort accelerated corneal collagen cross-linking in pediatric patients: two-year follow-up results
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176916/
https://www.ncbi.nlm.nih.gov/pubmed/25295278
http://dx.doi.org/10.1155/2014/894095
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