“Silent” mitral cells dominate odor responses in the olfactory bulb of awake mice

How wakefulness shapes neural activity is a topic of intense discussion; in the awake olfactory bulb, high activity with weak sensory-evoked responses were reported in mitral/tufted cells (M/TCs). Using blind whole-cell recordings, we find 33% of M/TCs to be “silent”, yet showing strong sensory resp...

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Autores principales: Kollo, Mihaly, Schmaltz, Anja, Abdelhamid, Mostafa, Fukunaga, Izumi, Schaefer, Andreas T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176944/
https://www.ncbi.nlm.nih.gov/pubmed/25064849
http://dx.doi.org/10.1038/nn.3768
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author Kollo, Mihaly
Schmaltz, Anja
Abdelhamid, Mostafa
Fukunaga, Izumi
Schaefer, Andreas T
author_facet Kollo, Mihaly
Schmaltz, Anja
Abdelhamid, Mostafa
Fukunaga, Izumi
Schaefer, Andreas T
author_sort Kollo, Mihaly
collection PubMed
description How wakefulness shapes neural activity is a topic of intense discussion; in the awake olfactory bulb, high activity with weak sensory-evoked responses were reported in mitral/tufted cells (M/TCs). Using blind whole-cell recordings, we find 33% of M/TCs to be “silent”, yet showing strong sensory responses - with weak or inhibitory responses in “active” neurons. Thus, a previously missed M/TC subpopulation can exert powerful influence over the olfactory bulb.
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spelling pubmed-41769442015-04-01 “Silent” mitral cells dominate odor responses in the olfactory bulb of awake mice Kollo, Mihaly Schmaltz, Anja Abdelhamid, Mostafa Fukunaga, Izumi Schaefer, Andreas T Nat Neurosci Article How wakefulness shapes neural activity is a topic of intense discussion; in the awake olfactory bulb, high activity with weak sensory-evoked responses were reported in mitral/tufted cells (M/TCs). Using blind whole-cell recordings, we find 33% of M/TCs to be “silent”, yet showing strong sensory responses - with weak or inhibitory responses in “active” neurons. Thus, a previously missed M/TC subpopulation can exert powerful influence over the olfactory bulb. 2014-07-27 2014-10 /pmc/articles/PMC4176944/ /pubmed/25064849 http://dx.doi.org/10.1038/nn.3768 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Kollo, Mihaly
Schmaltz, Anja
Abdelhamid, Mostafa
Fukunaga, Izumi
Schaefer, Andreas T
“Silent” mitral cells dominate odor responses in the olfactory bulb of awake mice
title “Silent” mitral cells dominate odor responses in the olfactory bulb of awake mice
title_full “Silent” mitral cells dominate odor responses in the olfactory bulb of awake mice
title_fullStr “Silent” mitral cells dominate odor responses in the olfactory bulb of awake mice
title_full_unstemmed “Silent” mitral cells dominate odor responses in the olfactory bulb of awake mice
title_short “Silent” mitral cells dominate odor responses in the olfactory bulb of awake mice
title_sort “silent” mitral cells dominate odor responses in the olfactory bulb of awake mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176944/
https://www.ncbi.nlm.nih.gov/pubmed/25064849
http://dx.doi.org/10.1038/nn.3768
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